DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and SLC22A24

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	560	Identity:	153/560 - (27%)
Similarity:	258/560 - (46%)	Gaps:	85/560 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LMGKLGEFGKYQ--FLQFFL---------QVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSL 63
            |:.::|..|::|  .:.||.         .||...|           |..|.|||::..:||.::
Human     6 LLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFT-----------AFTPSHRCWVPLLDNDTV 59

  Fly    64 SVTPWNSSAILA-------AIPLKPNGELESCLMF----------DPSSPGTN--TTINC-ERYV 108
            |.   |.:..|:       :|||..|...:.|..|          :.:.|.||  .|..| :.:|
Human    60 SD---NDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWV 121

  Fly   109 YDTTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLII 173
            ||.:.:.::...:|:.||:.:.:.::||::||.|...|.:..|.|:|:|||| :.|.....||.|
Human   122 YDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRK-IICKLCFLQLAI 185

  Fly   174 -GVGVAFIPEYFSFMVARYLLG-----IVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGG 232
             ....||.|.:..:.:.|:|.|     |:|:.      |:|::|...|..|::..:.....::.|
Human   186 SNTCAAFAPTFLVYCILRFLAGFSTMTILGNT------FILSLEWTLPRSRSMTIMVLLCSYSVG 244

  Fly   233 IMLVAGWGALIPDRQWLQ------VIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGL 291
            .||:.|....|.|...||      :|     .|||..|..: ||.|||.:..:..|.:..:.:..
Human   245 QMLLGGLAFAIQDWHILQLTVSTPII-----VLFLSSWKMV-ESARWLIINNQLDEGLKELRRVA 303

  Fly   292 RING-----SGIPVDKEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYY 351
            .|||     ..:..:......| |:..|...|:|  :..|||.|.|||:...:|...||.::.:|
Human   304 HINGKKNTEETLTTELVRSTMK-KELDAVRIKTS--IFSLFRAPKLRMRVFGLCFVRFAITVPFY 365

  Fly   352 GLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQGS 416
            ||.|:...|..|..|...:.|.|.|.:....:..|:.:|||..........||..:|..::.| .
Human   366 GLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQ-E 429

  Fly   417 TTSTAVVMA----GKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSF 477
            .....||:|    |.:..|.:.|.:::  .||.||::|::..|:.::..|...||.||:..|.::
Human   430 MQILRVVLATLGIGSVSAASNSASVHH--NELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAY 492

  Fly   478 DPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGEN 517
            .|.:|.:.:||..:::...::.||||.:.|:|.:|:|.||
Human   493 SPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVEN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	147/546 (27%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	107/391 (27%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	116/425 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020