DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and Slc22a29

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	578	Identity:	154/578 - (26%)
Similarity:	263/578 - (45%)	Gaps:	79/578 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDLMGKLGEFGKYQFLQF-FLQVLSGLTA---GMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPW 68
            ::|:.::|..|::|.||. ||.:|:.:..   ||...:    ||:|.|||::..:||.:.|.
Mouse     4 QELLNQVGSLGRFQILQIVFLFLLNAIVVPHIGMENFT----AAIPNHRCWVPILDNDTASD--- 61

  Fly    69 NSSAILA-------AIPLKPNGELESCLMF---------------DPSSPGTNTTINCERYVYDT 111
            |.|.||:       :|||..|..|:.|..|               :.|.|.|...:  :.:|||.
Mouse    62 NGSRILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCV--DGWVYDR 124

  Fly   112 TYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVG 176
            :.:.::...:|:.||:.:.:.::.:..||:|:|.|.:..|.|:|:.|||.:...:.|...|....
Mouse   125 SNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETC 189

  Fly   177 VAFIPEYFSFMVARYLLGI------VGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIML 235
            |||.|.:|.:...|:|.|:      |.|       .:|.:|...|....:..:........|.|:
Mouse   190 VAFAPSFFIYCSLRFLAGMSVEPISVNS-------HLLMLEWTSPKFLAMMAVLSSCAPNIGFMI 247

  Fly   236 VAGWGALIPDRQW--LQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGI 298
            :||...|.  |.|  ||:........||....||.||.|||.:..:..:.:..:.|...:||...
Mouse   248 LAGLAFLF--RIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMKN 310

  Fly   299 PVDKEYYVQKAKQQAAAE-EKSSAGLSDLFRTPNLRMK--TLNVCLCWFANSLVYYGLSLSAGKL 360
            ..|....:.:...:|..| .|:...|.|||.|..||.:  .|:....:|..|::  ||::....|
Mouse   311 SGDLTMEIVRTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSII--GLAVHLQHL 373

  Fly   361 YGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMA 425
            ..|..|:.|::..:.....:...|||:.:|||.....||...|:..::|.::.|...| ..::||
Mouse   374 SSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQEMQT-LRIIMA 437

  Fly   426 GKLLIAGSFA-----VIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVL 485
               .:||..:     |.:.::.||.||.:|.:|:|:..........|:||..|:.::...:|.:.
Mouse   438 ---TLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVATYYANLPWIF 499

  Fly   486 FGVVALISGFWVMFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKKRQNSVYPDDP 543
            :|..::.:.|.|..||||.|||:|:|..|     .|:.|.....|::        :||
Mouse   500 YGGFSIFNAFTVFLLPETKNQPLPDSTHD-----VGNDWKESRKGKR--------EDP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	145/536 (27%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	99/386 (26%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	108/422 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010