DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	571	Identity:	174/571 - (30%)
Similarity:	270/571 - (47%)	Gaps:	67/571 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSS--------- 62
            ::|::..:||||.:|...|.|..|...:.....:.:|.:...|:|.|...||...|
Mouse     4 VDDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPAE 68

  Fly    63 -LSVT---------------------PWNSSAILAAIPLKPNGELESCLMFDPSSPGTNTTINCE 105
             |:.|                     .||.|.:....||.......|.|   |.||       ||
Mouse    69 ELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHL---PLSP-------CE 123

  Fly   106 R-YVYDTTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALF 169
            . :||||.  .:|...::|.||...|...:.|:...||.|.|::.:|.:||:.|||.....:.|.
Mouse   124 HGWVYDTP--GSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLV 186

  Fly   170 QLIIGVGVAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIM 234
            ..:.||..|..|:|.|.::.|.|.|:| |.|:::.|:.|..|.||...|....|.:|..|..|::
Mouse   187 TSLSGVLTAVAPDYTSMLLFRLLQGMV-SKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLV 250

  Fly   235 LVAGWGALIPDRQWLQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIP 299
            .:||....|||.:|||:...|...|||.::|::.||||||..|.|..:||.|:.:..:.|....|
Mouse   251 GLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPP 315

  Fly   300 VDKEYYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNP 364
            .|    ::....:..|.|:.|...:||||||:||..||.:...||:.:::|.||.:..|....|.
Mouse   316 AD----LKMMCLEEDASERRSPSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANL 376

  Fly   365 YLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQG----STTSTAVVMA 425
            ||..|...|||||:...|:..:||:||....:...|..|..|::..:|...    :.|...:...
Mouse   377 YLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRM 441

  Fly   426 GKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLIT--LLDSFDPKIPAVLFGV 488
            |..::.....::   :|||:||.:||..|.:.|....|.|..||.:.  |::.:. .:|.:||||
Mouse   442 GATIVLQMVCLV---NAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQ-ALPLILFGV 502

  Fly   489 VALISGFWVMFLPETMNQPMPESIEDGENFGKGDTWFSQCAGRKKRQNSVY 539
            :.|.:|...:.||||....:||:||:.||.|:..:        |.::|::|
Mouse   503 LGLSAGAVTLLLPETKGVALPETIEEAENLGRRKS--------KAKENTIY 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	163/532 (31%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	122/376 (32%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	164/533 (31%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	130/400 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8821
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030