DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	551	Identity:	166/551 - (30%)
Similarity:	269/551 - (48%)	Gaps:	31/551 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSAI 73
            :::.::|..|.:|:|...|..|..|....|.|..:..|..|:|.|  ....|:||.  ||
Mouse     5 EILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHC--RPPPNASLE--PW----- 60

  Fly    74 LAAIPLKPNGELESCLMFD--PSSPGTNTTINCERYVYDTTYYKTSR-TI--DWNFVCDRRWMGA 133
              .:||.|||:.|.||.|.  |::...|.|........|...|.::| ||  :|:.||....:..
Mouse    61 --VLPLGPNGKPEKCLRFVHLPNASLPNDTQGATEPCLDGWIYNSTRDTIVTEWDLVCGSNKLKE 123

  Fly   134 IVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLGIVGS 198
            :.|:|||.|:..|....|.|:|:.|||.:..||.|.....|...||.|....:|:.|:|.| ...
Mouse   124 MAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCG-CSI 187

  Fly   199 AGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWLQVIYGLHGCLFLGH 263
            :|..:...:|.:|.|..:.|.:...|....:..|..::.|....:|..:|||:.......:|...
Mouse   188 SGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYAVPQWRWLQLSVSAAFFIFSLL 252

  Fly   264 WWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQKAK---QQAAAEEKSSAGLSD 325
            .||:.||.|||.:.|:.::|:..:.:....||.....:| ..|::.|   |:.....|...||||
Mouse   253 SWWVPESIRWLVLSGKFSKALKTLQRVATFNGKKEEGEK-LTVEELKFNLQKDITSAKVKYGLSD 316

  Fly   326 LFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLG 390
            |||...||..|..:.|.|||....||.|::...:...|.|::..|.|.|:.|:....:..:..||
Mouse   317 LFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSISYLG 381

  Fly   391 RRSITSTLMLGGGLCCIVAAYI-AQGSTTSTAVVMAGKLLIAGSFAVIYNYSAELFPTVVRNSAM 454
            ||.....|::..|:..:...:: ::.....||:.:.||..::|||:.::.|::||:|||:|.:.|
Mouse   382 RRITQGFLLILAGVAILALIFVSSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGM 446

  Fly   455 GLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGENFG 519
            |:.::.||:...:.||:.:.....|.||.|:||.:.|:.|....||.||:|:|:||:|||.::
Mouse   447 GISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLETLNRPLPETIEDIQD-- 509

  Fly   520 KGDTWFSQCAGRKKRQNSVYPDDPEQMVPLK 550
                |:.|   .||.:.....:...|.:|||
Mouse   510 ----WYQQ---TKKTKQEPEAEKASQTIPLK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	153/503 (30%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	110/374 (29%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	154/504 (31%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060