DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and SLC22A12

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_006718493.1	Gene:	SLC22A12 / 116085	HGNCID:	17989	Length:	578	Species:	Homo sapiens

Alignment Length:	574	Identity:	174/574 - (30%)
Similarity:	267/574 - (46%)	Gaps:	85/574 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVT-------VAAVPEHRCFIEGVDNSSL- 63
            |.||:|.||.|          |||..:...:.::.|.|       .||||.|||:...:|||:.
Human     6 LLDLVGGLGRF----------QVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

  Fly    64 -----SVTPWNSSAILA-AIPLKPNGELESCLMF--------DPSSPGTN----TTINC-ERYVY 109
                 |::|   .|:|| :||..||.....|..|        ||::..|:    .|..| :.:||
Human    61 ASILGSLSP---EALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122

  Fly   110 DTTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIG 174
            |.:.:.::....||.|||...:..:.|::::.|:..||...|..:|:.||:.|..||.|...::|
Human   123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMG 187

  Fly   175 VGVAFIPEY-----FSFMVARYLLGIVGSAG-------------------AYICGFVLTMELVG- 214
            ...||.|.:     |.|::|..:.|::.:.|                   |...|.:..||...
Human   188 TAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWTAA 252

  Fly   215 ---PTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQW--LQVIYGLHGCLFLGHWWWLDESPRWL 274
               |...|:..:.|.  |..|:.....:|.    |.|  ||::..:...|...:.|||.||.|||
Human   253 RARPLVMTLNSLGFS--FGHGLTAAVAYGV----RDWTLLQLVVSVPFFLCFLYSWWLAESARWL 311

  Fly   275 WMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQKAKQQAAAEEKS----SAGLSDLFRTPNLRMK 335
            ...||....:..:.:...|||.|...|.  ...:....|..||.|    .|.|..|.|.|.||.:
Human   312 LTTGRLDWGLQELWRVAAINGKGAVQDT--LTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFR 374

  Fly   336 TLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLML 400
            |....|||||....::||:|....|..|.:|:...:|:|:.|:.:..:.:|..||||...:..:|
Human   375 TCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLL 439

  Fly   401 GGGLCCIVAAYI--AQGSTTSTAVVMAGKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARL 463
            ..|||.:....:  ..|:..| |:.:.|...:..:|..|..||:||||||:|.:|:|||.|.||.
Human   440 LAGLCILANTLVPHEMGALRS-ALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG 503

  Fly   464 SGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGEN 517
            ...|.||:.||....|.:|.:::|.|.::||...:.||||.:.|:|::|:|.:|
Human   504 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQN 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	165/557 (30%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	119/406 (29%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	168/561 (30%)
SLC22A12	XP_006718493.1	MFS	122..541	CDD:119392	126/427 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.060