Protein Alignment CG6126 and SLC22A12

DIOPT Version :10

• Sequence 1: NP_650528.1
• Gene: CG6126 / 41967
• FlyBaseID: FBgn0038407
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 174/574 - (30%)
• Similarity: 267/574 - (46%)
• Gaps: 85/574 - (14%)

  Fly     7 LEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVT-------VAAVPEHRCFIEGVDNSSL- 63
            |.||:|.||.|          |||..:...:.::.|.|       .||||.|||:...:|||:.
Human     6 LLDLVGGLGRF----------QVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ 60

  Fly    64 -----SVTPWNSSAILA-AIPLKPNGELESCLMF--------DPSSPGTN----TTINC-ERYVY 109
                 |::|   .|:|| :||..||.....|..|        ||::..|:    .|..| :.:||
Human    61 ASILGSLSP---EALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVY 122

  Fly   110 DTTYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIG 174
            |.:.:.::....||.|||...:..:.|::::.|:..||...|..:|:.||:.|..||.|...::|
Human   123 DRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMG 187

  Fly   175 VGVAFIPEY-----FSFMVARYLLGIVGSAG-------------------AYICGFVLTMELVG- 214
            ...||.|.:     |.|::|..:.|::.:.|                   |...|.:..||...
Human   188 TAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWTAA 252

  Fly   215 ---PTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQW--LQVIYGLHGCLFLGHWWWLDESPRWL 274
               |...|:..:.|.  |..|:.....:|.    |.|  ||::..:...|...:.|||.||.|||
Human   253 RARPLVMTLNSLGFS--FGHGLTAAVAYGV----RDWTLLQLVVSVPFFLCFLYSWWLAESARWL 311

  Fly   275 WMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQKAKQQAAAEEKS----SAGLSDLFRTPNLRMK 335
            ...||....:..:.:...|||.|...|.  ...:....|..||.|    .|.|..|.|.|.||.:
Human   312 LTTGRLDWGLQELWRVAAINGKGAVQDT--LTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFR 374

  Fly   336 TLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRLGRRSITSTLML 400
            |....|||||....::||:|....|..|.:|:...:|:|:.|:.:..:.:|..||||...:..:|
Human   375 TCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLL 439

  Fly   401 GGGLCCIVAAYI--AQGSTTSTAVVMAGKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARL 463
            ..|||.:....:  ..|:..| |:.:.|...:..:|..|..||:||||||:|.:|:|||.|.||.
Human   440 LAGLCILANTLVPHEMGALRS-ALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG 503

  Fly   464 SGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGEN 517
            ...|.||:.||....|.:|.:::|.|.::||...:.||||.:.|:|::|:|.:|
Human   504 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQN 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	165/557 (30%)
SLC22A12	XP_006718493.1	MFS_OAT	109..541	CDD:340932	129/440 (29%)