DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6126 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_598741.2	Gene:	Slc22a13 / 102570	MGIID:	2143107	Length:	551	Species:	Mus musculus

Alignment Length:	523	Identity:	167/523 - (31%)
Similarity:	257/523 - (49%)	Gaps:	30/523 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSAIL 74
            :|.::|:||::|.....|..:....|...:...|.:.....|.|.:..|.|.:.:::.....||
Mouse     7 VMAEVGDFGRFQVRLTILMGIPNFLAAFFIFGQVFMVLDEAHHCSVSWVKNHTFNLSAAEQLAI- 70

  Fly    75 AAIPLKPNGELESCLMFDPS----------SPGTNTTINCER-YVYDTTYYKTSRTIDWNFVCDR 128
             :||....|..||||||.|.          |...|.|..|:. :.|.....::.:. :::.||||
Mouse    71 -SIPNDTAGRPESCLMFRPPPDSASLEDILSHRFNETQACDSGWDYPENRPQSLKK-EFDLVCDR 133

  Fly   129 RWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLL 193
            :.:....|:|||.|:..||:..|.:.|.:||:.......|...|..:..||:..:..::..|::|
Mouse   134 KNLKKTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQVLLSGITSMATAFVSSFELYLALRFVL 198

  Fly   194 GIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAG--WGALIPDRQW--LQVIYG 254
            . ..:||..:...||..|.|||:.||...:..|:..|.|.|::||  :|.    |.|  ||:...
Mouse   199 A-TANAGFLLSTNVLISEWVGPSWRTQAVVLAQSNVALGQMVLAGLAYGV----RNWRLLQITGT 258

  Fly   255 LHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQKAKQQAAAEEKS 319
            ....|...::|.|.||||||..|||..||..:|.|...:||.  |:..|...|...::..    .
Mouse   259 APVLLLFFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGR--PLSPELLNQLVPEKTG----P 317

  Fly   320 SAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVF 384
            |....||||.|:||..||.:...||.:|||||.||...|....:.|:...|.|.||.|.....|.
Mouse   318 SGNALDLFRHPHLRKVTLILIAVWFVDSLVYYSLSFQVGDFGLDIYVTQLIFGAVEMPGRFLSVL 382

  Fly   385 VLDRLGRR-SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIAGSFAVIYNYSAELFPTV 448
            ::::|||: |...||.|.|.:..|:........|..|.:.:.||...|.:|.:.|.|:||||||:
Mouse   383 MMEKLGRKWSQLCTLTLAGIMYIIIIFIPGDLPTVVTVLAVVGKFASAAAFTISYVYTAELFPTI 447

  Fly   449 VRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIE 513
            :|.:.|||.|:.:|:.|.:|||:.||:.:...||.|:||.:.:.:|.....||||..|.:.::::
Mouse   448 IRQTGMGLVSIFSRVGGIITPLVMLLEQYHQAIPMVIFGSLPIGAGLLCALLPETRGQTLKDTLQ 512

  Fly   514 DGE 516
            |.|
Mouse   513 DLE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	164/510 (32%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	127/375 (34%)
Slc22a13	NP_598741.2	2A0119	12..510	CDD:273328	164/511 (32%)
Slc22a13	NP_598741.2	MFS	139..500	CDD:119392	127/371 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060