DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and slc22a16

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_002936981.2	Gene:	slc22a16 / 100488673	XenbaseID:	XB-GENE-961385	Length:	567	Species:	Xenopus tropicalis

Alignment Length:	558	Identity:	180/558 - (32%)
Similarity:	277/558 - (49%)	Gaps:	41/558 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTP---- 67
            :|.|...:|.||::|.|.:|......::.|:|.|:.|.:|..|:..|  ...:|.|..:.|
Frog     1 MERLFDYVGHFGRFQALIYFSSAFQAISCGIHYLASVFIAITPKFIC--RAPENISSVLLPNAST 63

  Fly    68 ---------WNSSAILAAIPLKPNG---ELESCLMFDP--------SSPGTNTTINCER-YVYDT 111
                     |.....|  :..:.||   ||..|..|..        |..|..|..:|.. |.||.
Frog    64 LRLEDVWELWTPKDYL--VVKQENGDIWELNQCSRFKRENTSYLTYSYDGNKTLFSCSNGYYYDN 126

  Fly   112 TYYKTSRTIDWNFVCDRRWMGAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVG 176
            |..::|...||:.||:|.|:..::|..||.||..|||..|.:||:|||:.:...::..|.:.|:.
Frog   127 TNLESSIVTDWHLVCEREWLAKLIQPTFMFGVLIGAVIFGDIADRVGRRLILWLTSTGQFLFGIA 191

  Fly   177 VAFIPEYFSFMVARYLLGIVGSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGA 241
            |||..:|:||::.|:||.:| |:|.|:..||...|.||...|:...:...|.||.|:|:|:..|.
Frog   192 VAFTFDYYSFVIVRFLLAMV-SSGYYVVVFVYVTEYVGIKARSWASMHVHAFFAVGVMIVSLVGF 255

  Fly   242 LIPDRQW--LQVIYGLHGCLFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVD-KE 303
            |:  |.|  .|:|..|....|:...|.|.|:|.||:.||:..|...::....:.|....|.. .|
Frog   256 LV--RTWWMYQIILSLTTLPFVLCCWMLPETPFWLYSQGKHKEVEKLIGTIEKWNKISTPCKLSE 318

  Fly   304 YYVQKAKQQAAAEEKSSAGLSDLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLIL 368
            ....:..|:...:......:.|||...:...:|:.|.|.||..||.||..:|::..|.||.||.|
Frog   319 LCSVQETQKTEMDTLKKHSVLDLFYNWSFARRTVTVWLIWFTGSLGYYVFALNSVNLGGNEYLNL 383

  Fly   369 FIMGLVEFPSYITIVFVLDRLGRR-SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIAG 432
            |:...||.||||...|.:|::||| ::...|:|...:|.|:.......||.:.|:.|.||..||.
Frog   384 FLTSAVEIPSYIVACFGMDKIGRRNTLAPFLILSAVICGIIMLIPQDHSTVTIAMSMGGKFSIAV 448

  Fly   433 SFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWV 497
            :|.:||.|:|||:||:||:.|:|.|||..|:...:.|....|......:|.:|.|::|.::|...
Frog   449 AFGLIYLYTAELYPTIVRSLAVGSGSMMCRIGSVVAPFCVYLTDVWIFMPQMLVGIMAFLTGVLT 513

  Fly   498 MFLPETMNQPMPESIEDGENFGKGD-----TWFSQCAG 530
            :.||||:..|:..:||:....|..:     ...::|.|
Frog   514 LKLPETLGVPLTSTIEEAAEMGTNNRITKRKSITECKG 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	173/523 (33%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	130/374 (35%)
slc22a16	XP_002936981.2	MFS_SLC22A16_CT2	111..517	CDD:340933	143/408 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010