DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and slc22a31

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_012817743.1	Gene:	slc22a31 / 100485676	XenbaseID:	XB-GENE-6048942	Length:	558	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	133/550 - (24%)
Similarity:	220/550 - (40%)	Gaps:	108/550 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVD------NSSLSVTPWNSS 71
            ::|.||:|..|......|..:...|...|.:...|||.::|  :||.      |||     |.:|
Frog    10 RVGGFGRYTRLLAAATWLPNVALAMGFFSELMYTAVPSYQC--QGVSGDPCPGNSS-----WENS 67

  Fly    72 AILAAIPLKPNGELESCLMFDPSSPGTNTTINCERYVYDTTYYKTSRTI-DWNFVCDRRWMGAIV 135
                      :.:.:.|       ||        .:.:....:..|..: .|..:|||:|...:.
Frog    68 ----------SNQSQHC-------PG--------GWHFQAQGWLNSNIVTQWELLCDRQWKVPLE 107

  Fly   136 QTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLGIVGSAG 200
            :..:::|...|.:..|.:.|::||:..|..:.:..|.:||.|.|...||||:..|...| ...||
Frog   108 KISYLVGWLLGYIIFGCICDRLGRRAAFIGALVMALPLGVAVTFTSSYFSFLPLRAGFG-AALAG 171

  Fly   201 AYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWLQ-------VIYGLHGC 258
            .::..::..:||..|::|.:..:.....:..|.:|:.|...|..|.:.||       ::.|::.|
Frog   172 MFLSFYISRVELCSPSQRLMVTMIGGFFWVAGELLLPGMAVLCSDWRVLQGSITGTLMLLGVYWC 236

  Fly   259 LFLGHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIPVDKEYYVQKAKQQAAAEEKSSAGL 323
               ||..: .||||||....:..:....:....|.||..|..|      .:.|.....|..|  |
Frog   237 ---GHTLY-PESPRWLLATQQVEQCKSELHMFARANGINIGED------ASGQDHVFTEIDS--L 289

  Fly   324 SDLFRTPNLRMKTLNVC------LCWFANSLVYYGLSLSAG-----------KLYGNPYLILFIM 371
            .:.|..|    :..::|      |.| .|:|: .|.:...|           :::| ||:..|:.
Frog   290 CEGFPRP----QYYSICSIFGTRLIW-RNALI-LGFTAFIGCGIRPCFARNLQVFG-PYIPYFLQ 347

  Fly   372 GLVEFPSYITIVFVLDRLGRRSITSTLMLGGGLCCIVAAYIAQ--------------GSTTSTAV 422
            ...|..:.|.|...:...||||:.....:..|.|.::...:.|              ||..|.||
Frog   348 AGSEIVACILICICVSHCGRRSVLLLFTILTGFCSLLLLALTQLDLFIEASIVISVVGSLCSHAV 412

  Fly   423 VMAGKLLIAGSFAVIYNYSAELFPTVVRNSAMGLGSMCARLSGALTPLITLLDSFDPKIPAVLFG 487
            ||....           |:.|:.|||:|.|.:||......|..|..|.|.|.......:..|:..
Frog   413 VMLSVF-----------YACEVLPTVIRGSGLGLIMGINMLGRASLPFIELQHKSGYFLYHVVLS 466

  Fly   488 VVALISGFWVMFLPETMNQPMPESIEDGEN 517
            ...::|...::.||||..:.:||::..|||
Frog   467 SFCILSVLSLLLLPETKRKSLPETLRHGEN 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	128/539 (24%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	97/408 (24%)
slc22a31	XP_012817743.1	MFS	110..470	CDD:119392	95/390 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010