DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6126 and si:dkey-166k12.1

DIOPT Version :9

Sequence 1:	NP_650528.1	Gene:	CG6126 / 41967	FlyBaseID:	FBgn0038407	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_001341287.1	Gene:	si:dkey-166k12.1 / 100001249	ZFINID:	ZDB-GENE-120215-78	Length:	537	Species:	Danio rerio

Alignment Length:	518	Identity:	185/518 - (35%)
Similarity:	276/518 - (53%)	Gaps:	27/518 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDLMGKLGEFGKYQFLQFFLQVLSGLTAGMHMLSLVTVAAVPEHRCFIEGVDNSSLSVTPWNSSA 72
            :.|:..:|.|||||.|.:....|..:..|.||::.|...|.|.|||     ..|:..:..|..::
Zfish     4 DQLLATIGGFGKYQKLLYVWICLPQIFLGFHMMASVFTGATPPHRC-----RGSTSGMEDWTFTS 63

  Fly    73 ILAAIPLKPN---GELESCLMFDPSSPGTNTT--INCER-YVYDTTYYKTSRTIDWNFVCDRRWM 131
            .|:.:.|..:   |..::|    .::.|.|.:  .|||. :||....::::...:|:.|||:|.:
Zfish    64 NLSHVNLSISRLAGFADAC----TAASGVNRSARTNCETGWVYSHEVFQSTTVTEWDLVCDKRGL 124

  Fly   132 GAIVQTVFMLGVFTGAVTLGGLADKVGRKTVFCWSALFQLIIGVGVAFIPEYFSFMVARYLLGIV 196
            .::..:::|||:..|||..|.:||:.||:.....|...|.:.||..||.|.:..::..|:::|:.
Zfish   125 SSLGSSIYMLGLLVGAVVFGAMADRYGRRFAMLVSLALQTVFGVAAAFAPNFPVYVGLRFIIGMT 189

  Fly   197 GSAGAYICGFVLTMELVGPTKRTVCGITFQAVFAGGIMLVAGWGALIPDRQWLQVIYGLHGCLFL 261
            .| |..|..|||..|.....:|.:.||.....|..|.||:||...||.|.:.||:.....|.||:
Zfish   190 VS-GVIINAFVLGTEWTCTQRRMLAGIFTDYFFGFGYMLLAGVAFLIRDWRKLQLAISAPGFLFI 253

  Fly   262 GHWWWLDESPRWLWMQGRAAEAVDIVAKGLRINGSGIP--VDKEYYVQKAKQQAAAEEKSSAGLS 324
            .:.|.|..|.|||.:..|..||:|::.|...:||..:|  |..|.|       .:.:.:|...:.
Zfish   254 FYIWVLPHSARWLLVNNRKEEAIDLLRKAASVNGRTLPPTVQVERY-------ESPQGRSKYTVV 311

  Fly   325 DLFRTPNLRMKTLNVCLCWFANSLVYYGLSLSAGKLYGNPYLILFIMGLVEFPSYITIVFVLDRL 389
            ||.|||.:|.:.|.:...||.|.||||||||....|..:.||..|:.||||.|:. |:|.||...
Zfish   312 DLLRTPQMRKRALILFYIWFVNVLVYYGLSLGVSDLGADLYLTQFMFGLVEIPAR-TLVLVLLPC 375

  Fly   390 GRR-SITSTLMLGGGLCCIVAAYIAQGSTTSTAVVMAGKLLIAGSFAVIYNYSAELFPTVVRNSA 453
            .|: .::..|::|||.|.:.....|..:...||:.|.||..|..|||:||.|||||||||:|.:.
Zfish   376 SRKIPLSVFLVVGGGACLLTLTLPADSAHVRTALAMVGKFGITASFAIIYVYSAELFPTVLRQTG 440

  Fly   454 MGLGSMCARLSGALTPLITLLDSFDPKIPAVLFGVVALISGFWVMFLPETMNQPMPESIEDGE 516
            :|:.||.||:.|.|.|||.||....|.:|.::||...|::....:.||||..||:|:||.|.|
Zfish   441 IGVSSMFARMGGVLAPLINLLGRHTPVVPMLIFGSTPLLAAALALALPETARQPLPDSIHDTE 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6126	NP_650528.1	2A0119	15..510	CDD:273328	179/503 (36%)
CG6126	NP_650528.1	MFS	130..501	CDD:119392	138/373 (37%)
si:dkey-166k12.1	XP_001341287.1	2A0119	11..497	CDD:273328	179/503 (36%)
si:dkey-166k12.1	XP_001341287.1	MFS	123..458	CDD:119392	129/343 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.060