Protein Alignment CG8925 and SLC22A8

DIOPT Version :10

• Sequence 1: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_004245.2
• Gene: SLC22A8 / 9376
• HGNCID: 10972
• Length: 542
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 139/555 - (25%)
• Similarity: 234/555 - (42%)
• Gaps: 93/555 - (16%)

  Fly   147 TKLLERLLGCLTPWQSMWCALLSIFQAICTFHIFVYVFQIAPKDFWCARPENLMQMSVSEWRNIS 211
            :::|:| :|.:..:|.:..|:|.:.......|..:.:|..|.....|..|.|   .|...| .:.
Human     4 SEILDR-VGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHN---ASTGPW-VLP 63

  Fly   212 QSSNG----CLLLDVDYTQVTYENNQLINWPE----NATDLGYRQC---WHFEFSDVDGSAKTLV 265
            ...||    ||              :.::.|.    |.|......|   |.:     :.:..::|
Human    64 MGPNGKPERCL--------------RFVHPPNASLPNDTQRAMEPCLDGWVY-----NSTKDSIV 109

  Fly   266 QEFDLVCGRDIL-SLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVA 329
            .|:||||..:.| .:.::.|:.|...|.::.|.:|||||||..|.....:.:..|...|||.:..
Human   110 TEWDLVCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP 174

  Fly   330 MFMSLRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISY------VLSAGLAYLIR 388
            ::|..|.:.||....:|:.:.:|.||.|..:.|.      |:..|:.|      .:..||||.|.
Human   175 IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRA------IMSTALGYCYTFGQFILPGLAYAIP 233

  Fly   389 DWRHLQLAISWPWLI-MLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNG--------TSASL 444
            .||.|||.:|.|:.: .||.| |.|||.|||:..|:..:...::.|.|..||        :...|
Human   234 QWRWLQLTVSIPFFVFFLSSW-WTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEEL 297

  Fly   445 PSNYRKTLEAAVPRAVQSPPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWR--TTCLTL 507
            ..|.:|.:..|               ::|...:|               :|.....|  |.||:|
Human   298 KLNLQKEISLA---------------KAKYTASD---------------LFRIPMLRRMTFCLSL 332

  Fly   508 VIWLTLIIIYFGLTLHLSNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLC 572
            . |......|:.|.:.:...|.|:||...:.|.|:..:..|:||.:..:|...:....:||.|..
Human   333 A-WFATGFAYYSLAMGVEEFGVNLYILQIIFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGA 396

  Fly   573 CLATNLV--SNQTGVIALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALILVP 635
            .||...|  ..||....||...|..:.::.:.:..||:..|||::|..|:|:.||.:.:..::.|
Human   397 ILALTFVPLDLQTVRTVLAVFGKGCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSP 461

  Fly   636 FLWKLEHIDPLLPLNVMGVCGLIGAVAISLMKDVV 670
            .:.....:.|.:|..:.|:..|:|..|...:.:.:
Human   462 LVKITGEVQPFIPNIIYGITALLGGSAALFLPETL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	118/439 (27%)
SLC22A8	NP_004245.2	2A0119	11..503	CDD:273328	137/547 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	515..542