Protein Alignment CG8925 and SLC22A2

DIOPT Version :10

• Sequence 1: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 133/468 - (28%)
• Similarity: 225/468 - (48%)
• Gaps: 48/468 - (10%)

  Fly   213 SSNGCLLLDVDYTQVTYE-NNQLINWPENATDLGYRQC---WHFEFSDVDGSAKTLVQEFDLVCG 273
            |...|...:||:.|.|:: .:.|.:...|.:.|....|   |.:|   ..||  ::|.||:|||.
Human    85 SPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYE---TPGS--SIVTEFNLVCA 144

  Fly   274 RD-ILSLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVAMFMSLRVI 337
            .. :|.|.::...||...|::..|:|:|||||:..|:..|.|.:..|.::|.|.:....:..|:|
Human   145 NSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLI 209

  Fly   338 IGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQLAISWPWL 402
            .|..|....::.::|:.|.|..::|..:||...:...:..::.||:||.:..||.||..:|.|..
Human   210 QGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNF 274

  Fly   403 IMLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRAVQSPPEAT 467
            ..|..::.:|||||||::|.:..|...:|:..|:.||  .|||:
Human   275 FFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNG--KSLPA--------------------- 316

  Fly   468 TSVESKAVEADAPDPSASGHVNP--LLVVFSAKYWRTTCLTLVIWLTLIIIYFGLTLHLSNLGGN 530
             |::...:|.:     ....:||  |.:|.:.:..:.|.:.:..|.|..::|.||.:|:...|.|
Human   317 -SLQRLRLEEE-----TGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDN 375

  Fly   531 IYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCLATNLVSNQTGVIALATIAKCL 595
            ||::...:..||..:..:.||.:.::|.|.......::.|..|||:..:...  :..|..|..||
Human   376 IYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGD--LQWLKIIISCL 438

  Fly   596 --IGANNA--IIPTYTAMQYPTIVRNFGVGMGNLASGIALILVPFL-WKLEHIDPLLPLNVMGVC 655
              :|...|  |:....|..|||.:||.||.:.:....|..|:.||| ::|.:|...|||.|.||.
Human   439 GRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVL 503

  Fly   656 GLIGAVAISLMKD 668
            ||:....:.|:.:
Human   504 GLVAGGLVLLLPE 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	123/427 (29%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	133/468 (28%)
		Proline-rich sequence. /evidence=ECO:0000269|PubMed:26979622	284..288		3/3 (100%)