Protein Alignment CG8925 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 143/531 - (26%)
• Similarity: 238/531 - (44%)
• Gaps: 84/531 - (15%)

  Fly   170 IFQAIC----TF-HIFVYVFQIA--PKDFWCARP------ENLMQMSVSEWRNISQSSNG----- 216
            :|..:|    || .:||.|..:.  |..:||..|      |........||...:.:|.|
Human    21 VFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPE 85

  Fly   217 ----C--LLLDV--DYTQVTYE---NNQLINWPENATDL-GYRQCWHFEFSDVDGSAKTLVQEFD 269
                |  .||:.  |....|..   .:.|..:|..:..| ..|..|.:.     .:..|:|.|||
Human    86 RRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYA-----QAHSTIVSEFD 145

  Fly   270 LVC-GRDILSLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVAMFMS 333
            ||| ...:|.|.:....:|...||...|:.:||:||....:.......|.|.::||:.:..:|:.
Human   146 LVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVI 210

  Fly   334 LRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQLAIS 398
            .|.:.|.......:..:|:|.|:|..|.|.::||:..:...:..::..|:||.|.:|:.:||||:
Human   211 FRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAIT 275

  Fly   399 WPWLIMLSIWFW-LPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRAVQS 462
            .|..:.| :::| :|||||||:.:.:.|:...::.|.|:.||  ..|.|||.
Human   276 LPSFLFL-LYYWVVPESPRWLITRKKGDKALQILRRIAKCNG--KYLSSNYS------------- 324

  Fly   463 PPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWRTTCLTLVIWLTLIIIYFGLTLHLSNL 527
                    |....:.:..:||.      |.:|.:.:..:.|.:.:..|.|..::|.||.:.|..:
Human   325 --------EITVTDEEVSNPSF------LDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGII 375

  Fly   528 GGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCLATNLVSNQTGVIALATIA 592
            |||:||:..::|.||.....:.:|.:.::|.|.......::.|:.||.|..:..  |:..|.|..
Human   376 GGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPE--GIAWLRTTV 438

  Fly   593 KCL--IGANNA--IIPTYTAMQYPTIVRNFGVGMGNLASGI---ALILVPF-LWKLEHIDPLLPL 649
            ..|  :|...|  |:....:..|||.:|||||   :|.||:   ..|:.|| |::|..:...|||
Human   439 ATLGRLGITMAFEIVYLVNSELYPTTLRNFGV---SLCSGLCDFGGIIAPFLLFRLAAVWLELPL 500

  Fly   650 NVMG----VCG 656
            .:.|    :||
Human   501 IIFGILASICG 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	118/422 (28%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	143/531 (27%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		3/3 (100%)