Protein Alignment CG8925 and Slc22a3

DIOPT Version :10

• Sequence 1: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_062103.1
• Gene: Slc22a3 / 29504
• RGDID: 3701
• Length: 551
• Species: Rattus norvegicus
• Alignment Length: 534
• Identity: 146/534 - (27%)
• Similarity: 243/534 - (45%)
• Gaps: 95/534 - (17%)

  Fly   170 IFQAIC----TF-HIFVYVFQIA--PKDFWCARP------ENLMQMSVSEWRNIS---------- 211
            :|..:|    || .:||.|..:.  |..:||..|      |........|| |::
  Rat    21 VFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEEEW-NLTTPELHVPAER 84

  Fly   212 QSSNGC--LLLDVDYTQVTYENNQLINWPENATDLGYRQC---WHFEFSDVDGSAKTLVQEFDLV 271
            :....|  .||:...|......:.|..:|..:..|  ..|   |.:    |: :..|:|.:||||
  Rat    85 RGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPL--VPCSGDWRY----VE-THSTIVSQFDLV 142

  Fly   272 CGRD-ILSLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFG-GI----LAFSTSVAM 330
            ||.. :|.|.:....:|..|||...|:.:||:||     ..|.:.|.|| ||    :||:.:.::
  Rat   143 CGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGR-----LIVYLISCFGVGITGVVVAFAPNFSV 202

  Fly   331 FMSLRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQL 395
            |:..|.:.|.......:..||:|.|:|..|.|.::||:..:...:..::..|:||....|:.:||
  Rat   203 FVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTPSWQGIQL 267

  Fly   396 AISWPWLIMLSIWFW-LPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRA 459
            |||.|..:.| :::| :|||||||:.:.:.::...::.|.|:.||  ..|.|||.
  Rat   268 AISLPSFLFL-LYYWVVPESPRWLITRKQGEKALQILRRVAKCNG--KHLSSNYS---------- 319

  Fly   460 VQSPPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWRTTCLTLVIWLTLIIIYFGLTLHL 524
                       |....:.:..:||.      |.:|.:.:..:.|.:.:..|.|..::|.||.:.|
  Rat   320 -----------EITVTDEEVSNPSC------LDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRL 367

  Fly   525 SNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCLATNLVSNQTGV---- 585
            ..:|||:|::..::|.||.....:.:|.:.::|.|.......::.|:.||.|..:..  |:
  Rat   368 GLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPE--GIPWLR 430

  Fly   586 IALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGI---ALILVPF-LWKLEHIDPL 646
            ..:||:.:..|.....|:....:..|||.:|||||   :|.||:   ..|:.|| |::|..|...
  Rat   431 TTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGV---SLCSGLCDFGGIIAPFLLFRLAAIWLE 492

  Fly   647 LPLNVMG----VCG 656
            |||.:.|    |||
  Rat   493 LPLIIFGILASVCG 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	124/430 (29%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	146/534 (27%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O75751	284..288		3/3 (100%)