Protein Alignment CG8925 and Slc22a2

DIOPT Version :10

• Sequence 1: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_113772.1
• Gene: Slc22a2 / 29503
• RGDID: 61936
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 552
• Identity: 148/552 - (26%)
• Similarity: 247/552 - (44%)
• Gaps: 95/552 - (17%)

  Fly   170 IFQAICTFHIF-----------------VY---VFQIAPKDFWCARP--ENLMQ---MSVSEWRN 209
            |.:.|..||:|                 :|   ||.....|..|..|  ..|.|   .|.:|..|
  Rat     7 ILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQRCGWSQAEELN 71

  Fly   210 ISQSSNG----------CLLLDVDYTQVTY-----------ENNQLINWPENATDLGYRQCWHFE 253
            .:....|          |:..:||:.|.|.           :.|||...|          |.|..
  Rat    72 YTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLGP----------CEHGW 126

  Fly   254 FSDVDGSAKTLVQEFDLVCGRD-ILSLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSV 317
            ..:..||  ::|.||:|||... :|.|.::...||...||::.|:::|||||:..|:..:.|.::
  Rat   127 VYNTPGS--SIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAI 189

  Fly   318 FGGILAFSTSVAMFMSLRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAG 382
            .|.::|.|.:.|..:..|.:.|..|....::.::|:.|.|...:|.::||...:...:..::.||
  Rat   190 SGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGICYQIAFTVGLLILAG 254

  Fly   383 LAYLIRDWRHLQLAISWPWLIMLSIWFW-LPESPRWLLAQGRLDELCGLIERAARMNGTSASLPS 446
            :||:|.:||.||.|::.|....| ::|| :|||||||::|.::.:...:|:..|:.||.|
  Rat   255 VAYVIPNWRWLQFAVTLPNFCFL-LYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKS----- 313

  Fly   447 NYRKTLEAAVPRAVQSPPEATTSVESKAVEADAPDPSASGHVNP--LLVVFSAKYWRTTCLTLVI 509
                     ||.::|:.               .||..|...:.|  |.:|.:.:..:.|.:.:..
  Rat   314 ---------VPVSLQNL---------------TPDEDAGKKLKPSILDLVRTPQIRKHTLILMYN 354

  Fly   510 WLTLIIIYFGLTLHLSNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCL 574
            |.|..::|.||.:|:...|.|||::...:..||..:..|.||.:.:||.|.......::.|..||
  Rat   355 WFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACL 419

  Fly   575 ATNLVSN--QTGVIALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALILVPFL 637
            |:..:.:  |...|.:|.:.:..|.....::....|..|||.:||.||.:.:....|..|:.|||
  Rat   420 ASVFIPDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFL 484

  Fly   638 -WKLEHIDPLLPLNVMGVCGLIGAVAISLMKD 668
             ::|..|....||.|..|.||:....:.|:.:
  Rat   485 VYRLTDIWMEFPLVVFAVVGLVAGALVLLLPE 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	121/423 (29%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	146/547 (27%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15244	284..288		3/3 (100%)