DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8925 and SV2C

DIOPT Version :10

Sequence 1:NP_650526.1 Gene:CG8925 / 41963 FlyBaseID:FBgn0038404 Length:670 Species:Drosophila melanogaster
Sequence 2:NP_055794.3 Gene:SV2C / 22987 HGNCID:30670 Length:727 Species:Homo sapiens


Alignment Length:545 Identity:96/545 - (17%)
Similarity:177/545 - (32%) Gaps:190/545 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   286 VGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVAMFMSLRVIIGF--ASMTVTVV 348
            :|...||...|.::|:.||:.:|:..:::...|..:.:|......|:..|::.||  .....||.
Human   199 LGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVF 263

  Fly   349 SF---VLVVE-------------LVSGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQLAI 397
            |:   ||..|             ::.|.:.:.:. ..|:| ...:..|.|.||....||...:..
Human   264 SYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMA-WAIIP-HYGWSFSMGSAYQFHSWRVFVIVC 326

  Fly   398 SWPWLIMLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRAVQS 462
            :.|.:..:....::|||||:||..|:.||...:::.....|..:...|.      :......:::
Human   327 ALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPE------KVFTVNKIKT 385

  Fly   463 PPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKY--WRT------------TCLTLVIWLTL 513
            |.:....:|   :|:|    :.:.:....:.:.:..|  |.|            |....::|.||
Human   386 PKQIDELIE---IESD----TGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTL 443

  Fly   514 IIIYFGLT----------------LHLSNLGGNIYINSAVAGTVE-------------------- 542
            ...|:||:                |...|:..:.|.|..:..|:|                    
Human   444 SFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFK 508

  Fly   543 -------AISIC----------------------------------------------------- 547
                   ....|                                                     
Human   509 SVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITF 573

  Fly   548 -------------------------ISILVVLKVGIRRSLIGYMLLPGLCCLATNLVSNQTGVIA 587
                                     :|.|::.::|....|.|.|:|.|:.|......::::.:|.
Human   574 DDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIG 638

  Fly   588 LATIAKCL-IGANNAIIPTYTAMQYPTIVRNFGVG-----------MGNLASGIALILVPFLWKL 640
            :..:...| |.|.|: :...|...|||..|..|.|           :|||..|..:.:...:   
Human   639 MLCLYNGLTISAWNS-LDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSI--- 699

  Fly   641 EHIDPLLPLNVMGVCGLIGAVAISL 665
                |:|..:.:.|||  |.|.:.|
Human   700 ----PILLASTVLVCG--GLVGLCL 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8925NP_650526.1 MFS_SLC22 249..666 CDD:340875 96/545 (18%)
SV2CNP_055794.3 synapt_SV2 1..727 CDD:130366 96/545 (18%)
Interaction with SYT1. /evidence=ECO:0000250 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..84
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781 519..563 1/43 (2%)
Blue background indicates that the domain is not in the aligned region.

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