Protein Alignment CG8925 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: NP_033228.2
• Gene: Slc22a1 / 20517
• MGIID: 108111
• Length: 556
• Species: Mus musculus
• Alignment Length: 489
• Identity: 134/489 - (27%)
• Similarity: 224/489 - (45%)
• Gaps: 79/489 - (16%)

  Fly   203 SVSEWRNISQSSNGCLLLDVDYTQVTYE-NNQLINWPENATDLGYRQCWHFEFSDVDGSAKTLVQ 266
            |..|...:||    |:..:||:.|.|.: .:.|.:...|.:.|....|.|....|..||  ::|.
Mouse    79 SAGEASFLSQ----CMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTPGS--SIVT 137

  Fly   267 EFDLVCGRDI--LSLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSVFGGILAFSTSVA 329
            ||:|||| |.  :.|.::|..:|...|:::.|:|:|||||:..|:....:.|:.|.:.|.:....
Mouse   138 EFNLVCG-DAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGVLTAVAPDYT 201

  Fly   330 MFMSLRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQ 394
            ..:..|::.|..|....|..:.|:.|.|...:|....||..:...:..|..||:||.|.|||.||
Mouse   202 SMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAYAIPDWRWLQ 266

  Fly   395 LAISWPWLIMLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSASLPSNYRKTLEAAVPRA 459
            ||:|.|..:.|..::::||||||||:|.|..:...::|:.|:.|          ||.
Mouse   267 LAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKN----------RKV-------- 313

  Fly   460 VQSPPEATTSVESKAVEADAPD---PSASGHVNPLLVVFSAKYWRT------TCLTLVIWLTLII 515
               ||   ..::...:|.||.:   ||            .|..:||      |.:.:.:|.:..:
Mouse   314 ---PP---ADLKMMCLEEDASERRSPS------------FADLFRTPSLRKHTLILMYLWFSCAV 360

  Fly   516 IYFGLTLHLSNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPGLCCLATNLVS 580
            :|.||.:|:...|.|:|::...:..||..:..|.::.:.::|....:....|:.|..||....:.
Mouse   361 LYQGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIP 425

  Fly   581 NQTG--VIALATIAK----------CLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIALIL 633
            ::..  .:.||.:.:          ||:.|.          .|||.:||.|:.:.:....:..|.
Mouse   426 HELHWLNVTLACLGRMGATIVLQMVCLVNAE----------LYPTFIRNLGMMVCSALCDLGGIF 480

  Fly   634 VPFL-WKLEHIDPLLPLNVMGVCGL-IGAVAISL 665
            .||: ::|..:...|||.:.||.|| .|||.:.|
Mouse   481 TPFMVFRLMEVWQALPLILFGVLGLSAGAVTLLL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	122/442 (28%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	134/489 (27%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)