Protein Alignment CG8925 and SLC22A12

DIOPT Version :10

• Sequence 1: NP_650526.1
• Gene: CG8925 / 41963
• FlyBaseID: FBgn0038404
• Length: 670
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 145/510 - (28%)
• Similarity: 227/510 - (44%)
• Gaps: 73/510 - (14%)

  Fly   196 PENLMQMSVSEWRNISQSSNGCLLLDVDYTQVTYENNQLINWPENATDLGYRQCWHFEFSDVDG- 259
            ||.|:.:|:....|  |..:.|........|:...|....:|.|..|:    .|       |||
Human    69 PEALLAISIPPGPN--QRPHQCRRFRQPQWQLLDPNATATSWSEADTE----PC-------VDGW 120

  Fly   260 ------SAKTLVQEFDLVCGRDILS-LVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFVTIQSV 317
                  ...|:|.:::|||....|. :.::.:|.|...||...|..|||||||..|.......:|
Human   121 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAV 185

  Fly   318 FGGILAFSTSVAMFMSLRVIIGFASMTVTV-------------------------VSFVLVVELV 357
            .|...||:.:..::...|.::.||...|.:                         :..:.|:|..
Human   186 MGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWT 250

  Fly   358 SGKWRTVIGILNILPVAISYVLSAGLAYLIRDWRHLQLAISWPWLIMLSIWFWLPESPRWLLAQG 422
            :.:.|.::..||.|..:..:.|:|.:||.:|||..|||.:|.|:.:.....:||.||.||||..|
Human   251 AARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTG 315

  Fly   423 RLDELCGLIE--RAARMNGTSASLPSNYRKTLEAAVPRAVQSPPEATTSVESKAVEADAPDPSAS 485
            |||  .||.|  |.|.:||..|     .:.||          .||...|...:.:....| |::.
Human   316 RLD--WGLQELWRVAAINGKGA-----VQDTL----------TPEVLLSAMREELSMGQP-PASL 362

  Fly   486 GHVNPLLVVFSAKYWRTTCLTLVIWLTLIIIYFGLTLHLSNLGGNIYINSAVAGTVEAISICISI 550
            |   .||.:...::  .||::.:.|......:|||.|.|..||.||::.....|.|:..:...::
Human   363 G---TLLRMPGLRF--RTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGAL 422

  Fly   551 LVVLKVGIRRSLIGYMLLPGLCCLATNLVSNQTGVI--ALATIAKCLIGANNAIIPTYTAMQYPT 613
            |::..:|.|.:|...:||.|||.||..||.::.|.:  |||.:....:||....|..|::..:||
Human   423 LLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPT 487

  Fly   614 IVRNFGVGMGNLASGIALILVPFLWKLEHIDPLLPLNVMGVCGLIGAVAISLMKD 668
            ::|...||:|.:|:....||.|.:..|....|.|||.|.|...::..:|..|:.:
Human   488 VLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPE 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8925	NP_650526.1	MFS_SLC22	249..666	CDD:340875	132/453 (29%)
SLC22A12	XP_006718493.1	MFS_OAT	109..541	CDD:340932	135/465 (29%)