DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and SLC22A13

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	519	Identity:	152/519 - (29%)
Similarity:	259/519 - (49%)	Gaps:	53/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 MGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQH-------------MPVA 140
            :|.:|::|:.:.:||.:....:.|:..:.::...::...|.......|             :|:.
Human    11 IGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAWVKNHTFNLSAAEQLVLSVPLD 75

  Fly   141 TWRNLSGSVDNCRRW---------EGIDWSQVSNETTLPSDWKTPAEMDKKLVACEKWEYETN-- 194
            |    :|..:.|..:         :.| .|...|||       .|.:|.        |||..|
Human    76 T----AGHPEPCLMFRPPPANASLQDI-LSHRFNET-------QPCDMG--------WEYPENRL 120

  Fly   195 DNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLW 259
            .::.|    :::|||:::|||:..:..|:.|:..|.::.|.|.|:.|||..:....:|.|:.||.
Human   121 PSLKN----EFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLA 181

  Fly   260 LYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYL 324
            .....|||||:.||..:......:::|.:.|..|:|...|||.|.:.......:..|:::||||.
Human   182 TAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYG 246

  Fly   325 TQDYQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADY--QLT 387
            .::::.||:....||:.|.|.::.:|||.||||.:||:||..::|:.||..|.|:|..:.  ||.
Human   247 FRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLV 311

  Fly   388 PPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEIP 452
             |.:...:.:...|||...||::::..||:||..:|.|||:.|.:..||.:|||...:.|.||:|
Human   312 -PEKTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVP 375

  Fly   453 AIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITFLMMGKFTISAGNTIMPV 517
            |...:::::.:.|:||....||:..|:.|.......  |||..:.....::||...:|..||..|
Human   376 ARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIP--ADLPVVVTMLAVVGKMATAAAFTISYV 438

  Fly   518 YTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAWSIFGGFVVLFLPET 581
            |:|||:||.:|..|:|...:.:.:..||||.:.||.:....|.|.:..:..|..|.:...||||
Human   439 YSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPET 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	150/516 (29%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	118/358 (33%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	152/518 (29%)
		MFS	139..500	CDD:119392	118/363 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020