DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6006 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	512	Identity:	130/512 - (25%)
Similarity:	241/512 - (47%)	Gaps:	33/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 MGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQL---QHMPVATW--RNLSGS 148
            :|..|::|.:...|:.|..:....|.:...:.||.....|:.||..   ::..:..|  |:..|.
Human    10 VGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQ 74

  Fly   149 VDNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVAC-EKWEYETNDNVGNTWTSQWDLVCEKE 212
            .::|.|:....|.       ||....|.|........| :.|.|: |....:|..::|||||...
Human    75 PESCLRFTSPQWG-------LPFLNGTEANGTGATEPCTDGWIYD-NSTFPSTIVTEWDLVCSHR 131

  Fly   213 HLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSSFELYLTLRALLG 277
            .|:.:|:..:::||..|.::.|||:|:.||:.:|.::.:...:.|.......:|.:|...|.|.|
Human   132 ALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSG 196

  Fly   278 LVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQRLQLCIGIPGI-F 341
            :....::.:.:.|.:|::....|...|....:...:...:::|:||....::.|||.:..|.. |
Human   197 MALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAF 261

  Fly   342 LCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQ----------LPADYQ--LTPPTQESS 394
            ..:.||.: ||.||....||:|...|.::..|:.||::          |.|..|  ||....::|
Human   262 FIYSWFFI-ESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQAS 325

  Fly   395 TQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEIPAIAVAMY 459
            ..:   |.|...||.:.:|...:||..:..|||:::::..||.::||...:.|.|::||..|...
Human   326 AME---LLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFL 387

  Fly   460 IITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITFLMMGKFTISAGNTIMPVYTAELYP 524
            :|..:|::....|.|:.||:......:..  .|...::.:..::||..::|....:.:||.||||
Human   388 VINSLGRRPAQMAALLLAGICILLNGVIP--QDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYP 450

  Fly   525 TPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAWSIFGGFVVLFLPET 581
            |.||..|:|..:..|.:..|::|.:|:..::...:.:.:..|..:....|.:.||||
Human   451 TMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPET 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	128/509 (25%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	93/369 (25%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	130/511 (25%)
		MFS	135..505	CDD:119392	94/375 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020