DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and slc22a7a

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001077330.1	Gene:	slc22a7a / 794188	ZFINID:	ZDB-GENE-050506-52	Length:	560	Species:	Danio rerio

Alignment Length:	574	Identity:	160/574 - (27%)
Similarity:	260/574 - (45%)	Gaps:	88/574 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRP---------------- 131
            ||:.:: |.:.|:|.|:..:|.|.:|....|.....:.:......|..|
Zfish     5 DVLREI-GGFNKFQFLVLYILWLPRVILPLHFLLHNFISGVPPHHCALPRLDGRFSASGAEKEEL 68

  Fly   132 AQLQHMPVATWRNLSGSVDNCRRWEGIDWSQVSNETTLPSDWKTPAEM-------DKKLVACEK- 188
            ||:..:.:.  ||..||..:|:.:            |:|.|:....::       ....|.|:.
Zfish    69 AQIVALGIP--RNSDGSYSSCKMY------------TMPMDFDLNGDLSVLYGNRSNVSVPCQNG 119

  Fly   189 WEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQ 253
            |.|:.:.....|.| :|||||:.:.|......||.:||..|.::.|.||||||||.|:.:|.|..
Zfish   120 WVYDRSQFTSTTAT-EWDLVCDNKKLNQALATFFFIGVTMGAVVFGQLSDKFGRKPMIQVSFVSS 183

  Fly   254 TIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMII 318
            .:||:.....||:.::...|.|.|.....::.:.:.|.:|:.|.|.||..|........:..|::
Zfish   184 AVFGIIEAFSSSYVMFAIARTLCGFALTGMSITTVALCVEWTDVKHRTFTGTIISLGWSVGNMLL 248

  Fly   319 SGLAYLTQDYQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPAD 383
            :.||||.:|::.|.|.:..|.:.....|:.:|||.||||..||::|.::.:...||.||:
Zfish   249 ALLAYLIRDWRHLILVVTSPCLVGIIAWWWIPESARWLLANGRVEEAQKYLINCAKMNGK----- 308

  Fly   384 YQLTPPTQ----------ESSTQDVTY--LFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFG 436
            |..|....          |.|.::.:|  |.|:..||:|.:|....||.:...||||..|::.||
Zfish   309 YSYTKKLDIENLKKITIAEDSNKNHSYLDLVRTPKLRKIVLCSGIFWFAVAFTYYGISFNITGFG 373

  Fly   437 GNVYLNSALAGLVEIPAIAVAMYIITKVGKK----WLFCATLICAG--------VACCCAAITEG 489
            .|:||...:.|::|:||.......:.::|::    |    :||.||        :....||:..|
Zfish   374 LNIYLTQFIYGVIEVPAKVGTYLTLDRIGRRNGQAW----SLIIAGALIGLNSVIPTEFAAVRTG 434

  Fly   490 HADLLWLKITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNK 554
            .|          ::||....|..||..:||:|||||.:|..|:|..:..|.:...|.|.:.|...
Zfish   435 IA----------VIGKGFSEAAFTIAFLYTSELYPTVLRQCGLGYTSFIARIGGSLAPMVILFED 489

  Fly   555 IEGHLLMTLLTAWSIFGGFVVLFLPETAVRQKTDN-----QGGSSANASAAKQV 603
            |..:....:.:|.::|.|.||..||||...|..:|     :|..:.:..|.:.|
Zfish   490 IWHYGPPVVFSATAVFSGCVVFLLPETTNVQLPENILDVEEGRHTLSTEAERDV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	151/538 (28%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	116/380 (31%)
slc22a7a	NP_001077330.1	2A0119	11..523	CDD:273328	154/545 (28%)
slc22a7a	NP_001077330.1	MFS	148..514	CDD:119392	117/384 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010