DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and SLC22A4

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_003050.2	Gene:	SLC22A4 / 6583	HGNCID:	10968	Length:	551	Species:	Homo sapiens

Alignment Length:	540	Identity:	154/540 - (28%)
Similarity:	259/540 - (47%)	Gaps:	70/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DETDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRP--AQLQHMPVATW 142
            |..:||. .:|.:|.:|.|:..|||...:||.|:..|.::.|...:..|:.|  |.|.    :.|
Human     3 DYDEVIA-FLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLS----SAW 62

  Fly   143 RNLSGSV---------DNCRRW----------------EGIDWSQVSNETTLPSDWKTPAEMDKK 182
            ||.|..:         .:|.|:                ..:|..|:..|:.|
Human    63 RNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCL------------- 114

  Fly   183 LVACEKWEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLF 247
                :.||: :.|...:|..::|:||||......:....|.:||..|..:||.|||:||||.:||
Human   115 ----DGWEF-SQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLF 174

  Fly   248 ISAVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTI---AGMYNLF 309
            .:..:||.|........|:|::..|..::|:..:|......||..|.:....|.|   .|:...|
Human   175 ATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFF 239

  Fly   310 PLPISYMIISGLAYLTQDYQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAK 374
              .:.||::...||..:|::.|.|.:.:||:....||:.:|||||||:.:.|..|...||:.|||
Human   240 --AVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAK 302

  Fly   375 FNGRQLPADY-----QLTPPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSS 434
            .|...:||..     :|.|..|:.:.  :..|||:..:..::|....:|...::.|:.:.|:..:
Human   303 MNNIAVPAVIFDSVEELNPLKQQKAF--ILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPN 365

  Fly   435 FGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKIT 499
            ..|:.|||..|:.|:||||...|..::..:.::::..|.|...|.......:..  .|..:|.|.
Human   366 LHGDAYLNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVP--VDYYFLSIG 428

  Fly   500 FLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTP---YLSLLNKIEGHLLM 561
            .:|:|||.|::..:::.|:|||||||.:||:.||..:.|:.:..|:.|   ||...|::..:::|
Human   429 LVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVM 493

  Fly   562 TLLTAWSIFGGFVVLFLPET 581
            ..||   :..|.:.||.||:
Human   494 GSLT---VLIGILTLFFPES 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	150/528 (28%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	114/367 (31%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	151/530 (28%)
SLC22A4	NP_003050.2	MFS	123..508	CDD:119392	120/393 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010