Protein Alignment CG6006 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_001097812.1
• Gene: CG6006 / 41962
• FlyBaseID: FBgn0063649
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 144/532 - (27%)
• Similarity: 252/532 - (47%)
• Gaps: 61/532 - (11%)

  Fly    89 MGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKD-FWCQRPA------QLQHMPVATWRNLS 146
            :|.:|::|..:.:||.|..|...|.....::.....| :||:.|:      :....|...|...:
Human    11 VGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTA 75

  Fly   147 GSV---------DNCRRWEGIDWSQVSNETTLPSDWKTPAE-------MDKKLVACE-KWEYETN 194
            .:.         ..|:|:    ..:.:|::...:...:.|:       ....||.|. .|.|.
Human    76 PASRGPEPPERRGRCQRY----LLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYA-- 134

  Fly   195 DNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLW 259
             ...:|..|::||||....:.::.:....||..||....||.:|::||..:..:|.:...:.|:.
Human   135 -QAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVV 198

  Fly   260 LYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYL 324
            :....:|.:::..|.|.|:.......:..::..|.|..|.|.|.|:.......:..:|:.|:||.
Human   199 VAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYF 263

  Fly   325 TQDYQRLQLCIGIPG-IFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADY-QLT 387
            ..::|.:||.|.:|. :||.:.| |||||||||:.:.:.|:..:|:...||.||:.|.::| ::|
Human   264 IPNWQGIQLAITLPSFLFLLYYW-VVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEIT 327

  Fly   388 PPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEIP 452
            ...:|.|......|.|:..:|:.::.....|||..:||.|:::.:...|||:|::..::|:||:|
Human   328 VTDEEVSNPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELP 392

  Fly   453 AIAVAMYIITKVGKKWLFCATLICAGVACCCAA-ITEGHADLLWLKITFLMMGKFTISAGNTIMP 516
            ...:.:..|.::|::..|.|:.|.|||||...| :.||   :.||:.|...:|:..|:....|:.
Human   393 GALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEG---IAWLRTTVATLGRLGITMAFEIVY 454

  Fly   517 VYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAW------------SI 569
            :..:|||||.:||.||..|:.......|:.|:          ||..|...|            ||
Human   455 LVNSELYPTTLRNFGVSLCSGLCDFGGIIAPF----------LLFRLAAVWLELPLIIFGILASI 509

  Fly   570 FGGFVVLFLPET 581
            .||.|:| ||||
Human   510 CGGLVML-LPET 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	MFS_SLC22	189..579	CDD:340875	119/404 (29%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	144/531 (27%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		3/3 (100%)