Protein Alignment CG6006 and SLC22A1

DIOPT Version :10

• Sequence 1: NP_001097812.1
• Gene: CG6006 / 41962
• FlyBaseID: FBgn0063649
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: XP_005267160.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 573
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 148/508 - (29%)
• Similarity: 243/508 - (47%)
• Gaps: 66/508 - (12%)

  Fly    79 EDETDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATW- 142
            :|..:.:|: .|.:.|...|:..|||....|....|   ::.....|..||.|...:......|
Human     5 DDILEQVGE-SGWFQKQAFLILCLLSAAFAPICVGI---VFLGFTPDHHCQSPGVAELSQRCGWS 65

  Fly   143 --RNLSGSV-----------DNCRRWEGIDWSQ------------VSNETTLPSDWKTPAEMDKK 182
              ..|:.:|           ..|||:| :||:|            .:|.:.||
Human    66 PAEELNYTVPGLGPAGEAFLGQCRRYE-VDWNQSALSCVDPLASLATNRSHLP------------ 117

  Fly   183 LVACEK-WEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTML 246
            |..|:. |.|:|   .|::..::::|||......::.:.....|...|.:..||.:|:||||..|
Human   118 LGPCQDGWVYDT---PGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCL 179

  Fly   247 FISAVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYV-DGKWRTIAGMYNLFP 310
            ..:.::..:.|:.:....::...|..|.|.||||.....:|..|..|:| .|..||:|.||.: .
Human   180 LGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQM-A 243

  Fly   311 LPISYMIISGLAYLTQDYQRLQLCIGIPG-IFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAK 374
            ..:..:.::||||....::.|||.:.:|. :||.:.| .|||||||||.:.|..|..:|::..|:
Human   244 FTVGLVALTGLAYALPHWRWLQLAVSLPTFLFLLYYW-CVPESPRWLLSQKRNTEAIKIMDHIAQ 307

  Fly   375 FNGRQLPADYQLTPPTQESSTQDVTY--------LFRSSYLRRISICFFCIWFTMNLVYYGIILN 431
            .||:..|||.::.     |..:|||.        |||:..||:.:.....:|||.:::|.|:||:
Human   308 KNGKLPPADLKML-----SLEEDVTEKLSPSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILH 367

  Fly   432 MSSFGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWL 496
            |.:..||:||:...:.|||||...:|:..|.:||:.:....:.:.||.||.......  .||.||
Human   368 MGATSGNLYLDFLYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFIS--PDLHWL 430

  Fly   497 KITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYL 549
            .|..:.:|:..|:....::.:..||||||.:||:||..|:....:..|:||::
Human   431 NIIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFI 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	MFS_SLC22	189..579	CDD:340875	119/371 (32%)
SLC22A1	XP_005267160.1	2A0119	12..500	CDD:273328	147/501 (29%)