DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6006 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_071606.1	Gene:	Slc22a4 / 64037	RGDID:	621149	Length:	553	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	157/541 - (29%)
Similarity:	269/541 - (49%)	Gaps:	70/541 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DETDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATWRN 144
            |..:||. .:|.:|.:|.|:..|||...:||.|:..|.::.|...:..|..|..:...  :.|||
  Rat     3 DYDEVIA-FLGDWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPHTVNLS--SAWRN 64

  Fly   145 LSGSVD---------NCRRWE----------------GIDWSQVSNETTLPSDWKTPAEMDKKLV 184
            .|..::         :|||:.                .:|..|:..|:.|
  Rat    65 HSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGLDVDLEQLEQESCL--------------- 114

  Fly   185 ACEKWEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFIS 249
              :.||| :.|...:|..::|:||||.:....:....|.:||..|..:||.|||:||||.:||.:
  Rat   115 --DGWEY-SKDVFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFAT 176

  Fly   250 AVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTI---AGMYNLFPL 311
            ..:||.|.......:::|::..|.|::|:..:|......||..|.:....|.:   .|:...|
  Rat   177 MAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRILFSTLGVCTFF-- 239

  Fly   312 PISYMIISGLAYLTQDYQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFN 376
            .|.||::...||..:|::.|.|.:.:||:|...||:.:|||||||:.:.|.:|..:||:.|||.|
  Rat   240 AIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFEEAEQIIQKAAKMN 304

  Fly   377 GRQLPADYQLTPPTQ----ESSTQDVTY---LFRSSYLRRISICFFCIWFTMNLVYYGIILNMSS 434
            |...||  .:..|.:    .|..|...:   ||::..:..|::....:|...::.|:.:.||:.:
  Rat   305 GIMAPA--VIFDPLELQELNSLKQQKVFILDLFKTRNIATITVMSVMLWMLTSVGYFALSLNVPN 367

  Fly   435 FGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLIC-AGVACCCAAITEGHADLLWLKI 498
            ..|:||||..|:||:|:||...|..::..:.::::....|.. .||......:.|   |..::.|
  Rat   368 LHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLVQVVPE---DYNFVSI 429

  Fly   499 TFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTP---YLSLLNKIEGHLL 560
            ..:|:|||.:::..:::.|:|||||||.:||:.||..::|:.:..|:.|   ||...|::..::|
  Rat   430 GLVMLGKFGVTSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYIL 494

  Fly   561 MTLLTAWSIFGGFVVLFLPET 581
            |..||   :..|.:.||.||:
  Rat   495 MGSLT---VLIGIITLFFPES 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	153/529 (29%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	117/370 (32%)
Slc22a4	NP_071606.1	2A0119	12..519	CDD:273328	154/531 (29%)
Slc22a4	NP_071606.1	MFS	123..510	CDD:119392	123/396 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010