DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and SLC22A23

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	XP_011513103.1	Gene:	SLC22A23 / 63027	HGNCID:	21106	Length:	710	Species:	Homo sapiens

Alignment Length:	683	Identity:	164/683 - (24%)
Similarity:	262/683 - (38%)	Gaps:	163/683 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 APQERSQRSRSGTIPLCIMHDSAKQSP---TTSP-------TIPPKQQAATPQ----SPAAAVSG 72
            ||.|     .:|::|   ..|:|..:|   ...|       .:||......|.    |.|||.|.
Human    19 APAE-----ENGSLP---PGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSL 75

  Fly    73 LDPADDEDETDVIGDLMGHYGKWQLLMTVLLSLF----QVPNTFHISSSIYQAANKDFWCQRPAQ 133
            |....|......:|.|.|.|.|..:|:|.:.:||    |..::|.:.       ..:|||:...:
Human    76 LLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLD-------QPNFWCRGAGK 133

  Fly   134 ---------------------LQHMPVAT--WR------NLSGS--------------VDN---- 151
                                 |...|.||  |.      |.||:              .||
Human   134 GTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNC 198

  Fly   152 -CRRWE-GIDWSQVSN---------ET-TLPSDWKTPAEMDKKLVACEKWEYETNDNVGNTWTSQ 204
             ||.|: ||....|.|         || .||.|..|           ::|..|.|
Human   199 DCRAWDYGIRAGLVQNVVSKCCQQQETGALPWDTDT-----------KRWRPELN---------- 242

  Fly   205 WDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSSFELY 269
            |||||:.....::|:...|:|:..|.:|:|.::|..||:.:|..|.:...||||.:.:..:..::
Human   243 WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMF 307

  Fly   270 LTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQRLQLC 334
            .|||...|.....:..:...|.||......|.:..|...|.......::.|||.|.:|:|.||..
Human   308 STLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQAL 372

  Fly   335 IGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTPPTQESSTQDVT 399
            |..|.:.:...|.:.|||.|||:...:.:..:|:|....:.|......|.:...|..|..
Human   373 IICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELEKE----- 432

  Fly   400 YLFRSSYLRRISICFFCIWFTMN------------LVYYGI--------------ILNMSSFGGN 438
             |.|    |...:|...:..|.|            |..|||              :..:.:|..:
Human   433 -LSR----RPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYAD 492

  Fly   439 VYLNSALAGLVEIPAIAVAMYIITKVGKKWLF-----CATLICAGVACCCAAITE----GHADLL 494
            .|..:::| ||...|:.|.:..:.:.|...||     .|:|:..|:.......::    |.:|.:
Human   493 YYTTASIA-LVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSV 556

  Fly   495 WLK--ITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEG 557
            ..|  |.|.::|.|...|..::...:.||:.||.||..|:|....:||..::..|.:.|.|: :|
Human   557 KDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQ-KG 620

  Fly   558 HLLMTLLTA-WSIFGGFVVLFLPETAVRQKTDN 589
            :.|..::.| .::.....:|.|||:..:...:|
Human   621 YFLHHIIFACCTLICIICILLLPESRDQNLPEN 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	141/591 (24%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	95/394 (24%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	104/420 (25%)
SLC22A23	XP_011513103.1	MFS	259..>388	CDD:119392	35/128 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010