DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6006 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	525	Identity:	147/525 - (28%)
Similarity:	241/525 - (45%)	Gaps:	66/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 EDETDVIGDLMGHYGKWQ-LLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATW 142
            |:....:|: ||.|..:. .|:.|||.|:.......|                 |.:...|...|
Human     4 EEAFQAVGE-MGIYQMYLCFLLAVLLQLYVATEAILI-----------------ALVGATPSYHW 50

  Fly   143 RNLSGSVDNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVACEKWEYETNDNVGNTWT---SQ 204
             :|:..:.|  :..|   :|.:.|.....||         |:.....|...:.:..:::|   |:
Human    51 -DLAELLPN--QSHG---NQSAGEDQAFGDW---------LLTANGSEIHKHVHFSSSFTSIASE 100

  Fly   205 WDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSSFELY 269
            |.|:..:.:..:.|..||..||..|.|..|.|||:||||.:......|..:|.:......|:|.:
Human   101 WFLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFF 165

  Fly   270 LTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYN--LFPLPISYMIISGLAYLTQDYQRLQ 332
            ...|.|:|:::..::....:|..|.|...:..:||...  .|.:.|:...:  |.|..:.::.|.
Human   166 AVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYAL--LGYFIRSWRTLA 228

  Fly   333 LCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTPPTQESSTQD 397
            :.:.:.|..:..|...:|||||||..:||:.|....:...||.| |:|...:.||.|...|..:.
Human   229 ILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRN-RKLKCTFSLTHPANRSCRET 292

  Fly   398 VTY--LFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEIPAIAVAMYI 460
            .::  |||...|...::....|||..:|||||:.|:....||::|.|.||:||:|||:..:.:|:
Human   293 GSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPLCIYL 357

  Fly   461 ITK--VGKKWLFCATLICAGVACCCA------------AITEGHADLLWLKITFLMMGKFTISAG 511
            |.:  .|:|....|.|...|:||...            |:...|        :..::||.||||.
Human   358 INQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSH--------SLSLLGKLTISAA 414

  Fly   512 NTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAWSIFGGFVVL 576
            ..|:.:||:|||||.|||||:|.|::.:.:..|:.|::..|..::..|...:..|..:..|.:.|
Human   415 FNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSL 479

  Fly   577 FLPET 581
            .||||
Human   480 LLPET 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	142/512 (28%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	114/374 (30%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	113/368 (31%)
		MFS_1	111..450	CDD:284993	110/349 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920