DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6006 and SLC22A17

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_065105.3	Gene:	SLC22A17 / 51310	HGNCID:	23095	Length:	649	Species:	Homo sapiens

Alignment Length:	480	Identity:	112/480 - (23%)
Similarity:	187/480 - (38%)	Gaps:	91/480 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 SQVSNETTLPSDWKTPAEMDKKLVACEKWEYE-----TNDNVGNTWTSQWDLVCEKEHLKNVAEM 220
            |:|:..|........|.:.:..|   :.|:|.     |.:.:|     ||||||:......:.::
Human   160 SRVATSTDPSCSGFAPPDFNHCL---KDWDYNGLPVLTTNAIG-----QWDLVCDLGWQVILEQI 216

  Fly   221 FFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTY 285
            .|:||.|:|.:..||.:|:|||:.::.::..|....|:......|....:.||.|||.:...|..
Human   217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDL 281

  Fly   286 SGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQRLQL-----CI-----GIPGI 340
            ...::.:|..|...|....:.........:.:..|||.:::|::.||.     ||     |.||:
Human   282 GVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGL 346

  Fly   341 FLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTPPTQES-----------S 394
            ||        ||.|||:||.:|:|.:.::...|:   |..|....|....||:           :
Human   347 FL--------ESARWLIVKRQIEEAQSVLRILAE---RNRPHGQMLGEEAQEALQDLENTCPLPA 400

  Fly   395 TQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGG-----NVYLNSALAGLVEIPAI 454
            |...::....:| |.|......:.|| |.:.:.|.......||     :.||.|.||......|.
Human   401 TSSFSFASLLNY-RNIWKNLLILGFT-NFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALAC 463

  Fly   455 AVAMYIITKVGKKWLFCATLICAGVACC-------C---------------------AAITEGHA 491
            ......:.:.|::.:...::...|:|..       |                     ||||
Human   464 VFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAQQGNPNRDLNEAAIT---- 524

  Fly   492 DLLWLKITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIE 556
                   ||.::|.|:..|...:..:..||:.||.:|..|:|.......|..:..|...|.....
Human   525 -------TFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHG 582

  Fly   557 GHLLMTLLTAWSIFGGFVVLFLPET 581
            ..|...:|.|.::.....::.||||
Human   583 AFLQHVVLAACALLCILSIMLLPET 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	110/478 (23%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	93/410 (23%)
SLC22A17	NP_065105.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010