DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and CG8925

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_650526.1	Gene:	CG8925 / 41963	FlyBaseID:	FBgn0038404	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	622	Identity:	200/622 - (32%)
Similarity:	315/622 - (50%)	Gaps:	112/622 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PPKQQAATPQSPAAAVSGLDPADDEDETDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISS--- 116
            ||..: .|.|.|:.     |.:.||| :|||.:.:|||.:|..|.|:||.|||:|.|||:..
  Fly    63 PPSAE-QTEQPPSR-----DLSQDED-SDVISNFLGHYTRWSFLWTLLLCLFQLPTTFHLFMFVF 120

  Fly   117 ------------------------------------------------SIYQA------------ 121
                                                            ||:||
  Fly   121 QLTDVRSGEASPMLSDGNMENLDLLHTKLLERLLGCLTPWQSMWCALLSIFQAICTFHIFVYVFQ 185

  Fly   122 -ANKDFWCQRPAQLQHMPVATWRNLSGSVDNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVA 185
             |.|||||.||..|..|.|:.|||:|.|.:.|...: :|::||:.|.....:|...| .|.....
  Fly   186 IAPKDFWCARPENLMQMSVSEWRNISQSSNGCLLLD-VDYTQVTYENNQLINWPENA-TDLGYRQ 248

  Fly   186 CEKWEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISA 250
            |..:|:...|....|...::||||.::.| ::.|..||:|.|.|.::||::||:|||:..|....
  Fly   249 CWHFEFSDVDGSAKTLVQEFDLVCGRDIL-SLVETCFLVGAAAGAVLSGWISDRFGRRHTLMAFV 312

  Fly   251 VLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISY 315
            .:|::||..|...:|..::::||.::|..|::||....:|.:|.|.|||||:.|:.|:.|:.|||
  Fly   313 TIQSVFGGILAFSTSVAMFMSLRVIIGFASMTVTVVSFVLVVELVSGKWRTVIGILNILPVAISY 377

  Fly   316 MIISGLAYLTQDYQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNG--R 378
            ::.:|||||.:|::.|||.|..|.:.:..:||.:||||||||.:||:||:..:||.||:.||  .
  Fly   378 VLSAGLAYLIRDWRHLQLAISWPWLIMLSIWFWLPESPRWLLAQGRLDELCGLIERAARMNGTSA 442

  Fly   379 QLPADYQLT-----------PPTQESSTQD------------------VTYLFRSSYLRRISICF 414
            .||::|:.|           ||...:|.:.                  :..:|.:.|.|  :.|.
  Fly   443 SLPSNYRKTLEAAVPRAVQSPPEATTSVESKAVEADAPDPSASGHVNPLLVVFSAKYWR--TTCL 505

  Fly   415 -FCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAG 478
             ..||.|:.::|:|:.|::|:.|||:|:|||:||.||..:|.:::.::.|||.:......::..|
  Fly   506 TLVIWLTLIIIYFGLTLHLSNLGGNIYINSAVAGTVEAISICISILVVLKVGIRRSLIGYMLLPG 570

  Fly   479 VACCCAAITEGHADLLWLKITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLAL 543
            :.|....:......:    |....:.|..|.|.|.|:|.|||..|||.:||.|||..|:|:|:||
  Fly   571 LCCLATNLVSNQTGV----IALATIAKCLIGANNAIIPTYTAMQYPTIVRNFGVGMGNLASGIAL 631

  Fly   544 ILTPYLSLLNKIEGHLLMTLLTAWSIFGGFVVLFLPE 580
            ||.|:|..|..|:..|.:.::....:.|...:..:.:
  Fly   632 ILVPFLWKLEHIDPLLPLNVMGVCGLIGAVAISLMKD 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	188/587 (32%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	135/388 (35%)
CG8925	NP_650526.1	MFS	277..667	CDD:119392	137/396 (35%)
CG8925	NP_650526.1	MFS_1	277..635	CDD:284993	131/364 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3BMR2
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13331at6656
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.970