DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and slc22a6l

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	554	Identity:	150/554 - (27%)
Similarity:	271/554 - (48%)	Gaps:	71/554 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 MGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQ---AANKDFWCQRPAQLQ------------HMP 138
            :|..|::|:|...|||:   |.....|.::.|   ||.....||..|.|.            .:|
Zfish    10 VGSTGRFQVLHVTLLSM---PILMMASHNLLQNFVAAVPPHHCQPHANLSMSSTDAMDVLRATVP 71

  Fly   139 VATWRNLSGSVDNCRRWEGIDWSQVSNETTLPSDW-KTPAEMDKKLVACEK-WEYETNDNVGNTW 201
            :    .|:|.::.|:|:....| |:.:..|..|.| ::.||.:.:  :||. |.|...: :.:|.
Zfish    72 L----GLNGKLERCKRYTTPQW-QILSLNTSESLWDESMAETETQ--SCEDGWFYNMTE-MSSTI 128

  Fly   202 TSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSSF 266
            .::|||||:...||.:::..::.||..|.|:.|.|||:|||:.:|.||.::..|.|..:...:||
Zfish   129 ITEWDLVCDYRALKQMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAIGGTCVAFSTSF 193

  Fly   267 ELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQRL 331
            .::...|...|:....:..:...|.:|::..:.||:.|....:......:|::.:||..:|::.|
Zfish   194 TMFCVFRVCCGMALSGLVLNSFSLIVEWIPTRVRTVVGTGTGYCYTTGQLILAAVAYCIRDWRWL 258

  Fly   332 QLCIGIPGIFLCFL---WFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTPPTQES 393
            .|.:.:| .::.||   ||:  ||.|||::..:.::..:.::..|:.|||....|.......|||
Zfish   259 TLAVSLP-FYVSFLYSWWFL--ESARWLVLTKKPEQAVKNLKTVARINGRSAEGDKIDLEMLQES 320

  Fly   394 STQDV-----TY----LFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLV 449
            ..:::     :|    |.|:|.:|.|:||...:||:.:..|||:.:::..||.::||...:.|.|
Zfish   321 MKKEMACSKGSYSALDLLRTSTMRTITICLSAVWFSTSFAYYGLSMDLQKFGVSIYLIQIIFGAV 385

  Fly   450 EIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITFLMMGKFTISAGNTI 514
            :|||..:....::.:|::...|..|:.||:......:..  :||..|:.:..::||..::|....
Zfish   386 DIPAKIIVTICMSMLGRRPSQCGALVLAGIMILINLLVP--SDLQMLRTSLAVIGKGCLAASFNC 448

  Fly   515 MPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNK----IEGHLLMTLLTAWSIFGGFVV 575
            ..:|..|||||.||..|:|..::.|....::.|.:.||..    |.|.          |:||..:
Zfish   449 CYLYAGELYPTVIRQSGMGWVSMMARFGAMVAPMVLLLGDDYPWIPGF----------IYGGAPI 503

  Fly   576 L------FLPETAVR------QKTDNQGGSSANA 597
            :      |||||..:      |..|::|.:..|:
Zfish   504 VSGIFAFFLPETLSQPLPDTIQDIDDRGLARTNS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	144/529 (27%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	102/378 (27%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	146/537 (27%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	112/412 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020