DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6006 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001032838.1	Gene:	Slc22a14 / 382113	MGIID:	2685974	Length:	629	Species:	Mus musculus

Alignment Length:	495	Identity:	131/495 - (26%)
Similarity:	229/495 - (46%)	Gaps:	55/495 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VSGLDPADDEDETDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQL 134
            :..:|...|:....|: |.:|.:|.:|..:.||..:..:.:||.|.|..:....:..:|.....|
Mouse    40 LKAIDARRDDKFASVM-DAIGEFGTFQWRLVVLTFIPSILSTFFIFSHHFLLTAQRPYCNTSWIL 103

  Fly   135 QHMPVATW---------RNLSGSVDNCRRWEGIDWSQVS------NET-TLPSDWKTPAEMDKKL 183
            :..|..|.         |..:||...|..:..:.|...|      |.| |....|..|....:.|
Mouse   104 EVGPNLTEDEQLNLTLPRAPNGSFLTCLMYIPVPWDLDSIIHFGLNYTETCKFGWIYPFAHTRSL 168

  Fly   184 VACEKWEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFI 248
            :                  :::||||..|..|......||.||.||.::.|:||||.||..::.:
Mouse   169 I------------------NEFDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILL 215

  Fly   249 SAVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPI 313
            |.:...|||......|||..||..|..:...||......:.|.:|::.|:.|..|.:.....|.|
Mouse   216 SLLGFLIFGFGTAFVSSFYQYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAVILQHSFLTI 280

  Fly   314 SYMIISGLAYLTQDYQRLQLCIGIPGI-FLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNG 377
            ..::::||||....::.|.|..|:|.. .:|.:| |:.||||||:|:|:::|.::::..||:.|.
Mouse   281 GVILLTGLAYKVVHWRLLCLLGGMPMFPLICNIW-VLRESPRWLMVRGKVEEAKKVLCYAAEVNK 344

  Fly   378 RQLPADY--QLTPPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVY 440
            :.:|.:.  :|....::.:...:.....:.:|.::.:...|:|||::.:.:.:.|.|:.||.:||
Mouse   345 KTIPLNLLNELQISGKKVAKASILDFCTNQHLFKVVLAIGCVWFTVSYISFTLNLKMNDFGLDVY 409

  Fly   441 LNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLK-------I 498
            ....:..:|.:||....:.::...|:||....||......|..         ||:|.       |
Mouse   410 FVQMVRSIVAVPARLCCIILLEYFGRKWALNLTLFLVTSMCLF---------LLFLPQEPKSTII 465

  Fly   499 TFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVA 538
            ..||:.:|:::...:|..:|||||.||.:|:.|:|..::|
Mouse   466 LTLMLAEFSMAGTLSIFFIYTAELLPTVLRSTGLGMVSLA 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	127/475 (27%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	96/327 (29%)
Slc22a14	NP_001032838.1	2A0119	59..553	CDD:273328	127/475 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020