DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_941052.1	Gene:	Slc22a20 / 381203	MGIID:	2685809	Length:	556	Species:	Mus musculus

Alignment Length:	542	Identity:	155/542 - (28%)
Similarity:	257/542 - (47%)	Gaps:	44/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 TDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQH---------M 137
            ||:: |.:|..|::||:.|.||.|.......|.....:.||.....||.||....         :
Mouse     4 TDLL-DALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEPTTNVSGVWL 67

  Fly   138 PVATWRNLSGSVDNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVACEKWEYETNDNVGNTWT 202
            ..|...|..|..:.|||:....|:.:....   |......|..|     :.|.|: .....:|..
Mouse    68 RAAIPLNQHGDPEPCRRYVEPQWALLKPNA---SSHGVATEGCK-----DGWVYD-RSIFPSTIV 123

  Fly   203 SQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSSFE 267
            .:||||||...|:::|:..::.||..|..:.|.|:|:.|||..|..|.:...:.|.......||.
Mouse   124 MEWDLVCEARTLRDLAQSIYMSGVLVGAALFGGLADRLGRKAPLVWSYLQLAVSGAATAYVGSFS 188

  Fly   268 LYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQRLQ 332
            .|...|.|:|:....:..:.|.|.:|::..:.||:||:...|...:..:|::|:|||.:.::.||
Mouse   189 AYCVFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAGVAYLIRPWRWLQ 253

  Fly   333 LCIGIPG-IFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTPPTQESSTQ 396
            ..:..|. :|..:.|: :|||.||||:.|:..:..:.::..|..|||:...: :||.....|..|
Mouse   254 FAVSAPFLVFFLYSWW-LPESSRWLLLHGKAQQAVQNLQKVAMMNGRKAEGE-RLTTEVVSSYIQ 316

  Fly   397 D----------VTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEI 451
            |          :..|||:..:||::.|...:||:.::.|||:.:::..||.::||..||.|:::|
Mouse   317 DEFASVRTSNSILDLFRTPAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDI 381

  Fly   452 PAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITFLMMGKFTISAGNTIMP 516
            ||:.||...:..||::....:.||.||:.........  .||..|:.....:||..:::....:.
Mouse   382 PAMLVATTTMIYVGRRATVSSFLILAGLMVIANMFMP--EDLQTLRTVQAALGKGCLASSFICVY 444

  Fly   517 VYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAWSIFGGF-VVLFLPE 580
            ::|.|||||.||.:|:|..:|.|.|..::.|.::.|.:|...|......|.|:..|. |..||.|
Mouse   445 LFTGELYPTEIRQMGMGFASVNARLGGLVAPLITTLGEISPVLPPVSFGATSVLAGMAVACFLTE 509

  Fly   581 T---------AVRQKTDNQGGS 593
            |         |..::...||.|
Mouse   510 TRNVPLVETIAAMERRVKQGRS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	146/511 (29%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	109/368 (30%)
Slc22a20	NP_941052.1	2A0119	11..518	CDD:273328	148/519 (29%)
		MFS	138..507	CDD:119392	109/372 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..556		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020