DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	145/599 - (24%)
Similarity:	249/599 - (41%)	Gaps:	116/599 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DLMGHYGKWQLLMTV-------------LLSLFQVPNTFH------ISSSIYQAA-----NKDFW 127
            |.:|..|::|||..|             :|..|......|      :.:|..||:     .:|..
  Rat     8 DRVGGRGRFQLLQAVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPGDFGRDVL 72

  Fly   128 C---------QRPAQLQHMPVATWRNLSGSVDNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKL 183
            .         |||.|                  |.|:....|..:.:.|| .::|.     |...
  Rat    73 LAVSIPPGPDQRPHQ------------------CLRFRQPQWQLIESNTT-ATNWS-----DADT 113

  Fly   184 VACEK-WEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLF 247
            ..||. |.|: :....:|..:.|||||:.:.|:.:|:..||.|:..|..:.|:.||:|||:.:|.
  Rat   114 EPCEDGWVYD-HSTFRSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLT 177

  Fly   248 ISAVLQTIFGLWLYICSSFELYLTLRALLGLVSVSV-------------------------TYSG 287
            .|.:|.::.|....:..:|.||...|.|:......|                         |.|.
  Rat   178 WSYLLVSVSGTIAALMPTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPELTPSL 242

  Fly   288 LILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQRLQLCIGIP-GIFLCFLWFVVPE 351
            |:..:|:...:...:....|........::...:||..:.::.|||.:..| .:|..:.|: :||
  Rat   243 LLAVMEWTSAQAGPLMMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWW-LPE 306

  Fly   352 SPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTPPTQESSTQDV-----------TYLFRSS 405
            |.|||:..||:|:..|.::..|..|.|:..|| .||.....|:.|:.           |.|....
  Rat   307 SARWLITVGRLDQSLRELQRVAAVNRRKAEAD-TLTVEVLRSAMQEEPNGNQAGARLGTLLHTPG 370

  Fly   406 YLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLF 470
            ...|..|...| ||.....:||:.|::.:.|.|::|..||.|:|::|....::.:::::|::...
  Rat   371 LRLRTFISMLC-WFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLCQ 434

  Fly   471 CATLICAGVACCCAAITEGHADLLWLKITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGAC 535
            .::|:..|: |..|.|.... ::..|:.:..::|..::.|..|.:.::::||:||.||...||..
  Rat   435 ASSLVLPGL-CILANILVPR-EMGILRSSLAVLGLGSLGAAFTCVTIFSSELFPTVIRMTAVGLG 497

  Fly   536 NVAAGLALILTPYLSLLNKIEGHLLMTLLTAWSIFGGFVVLFLPET---------------AVRQ 585
            .|||....:|.|.:.||......|.:.:.....:..|...|.||||               :|::
  Rat   498 QVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKK 562

  Fly   586 KTDNQGGSSANASA 599
            .|.:..|.|...||
  Rat   563 VTHDIAGGSVLKSA 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	136/561 (24%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	98/393 (25%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	111/442 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020