DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	539	Identity:	160/539 - (29%)
Similarity:	269/539 - (49%)	Gaps:	66/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 DETDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATWRN 144
            |..:||. .:|.:|.:|.|:..|||...:||.|:..|.::.|...:..|..|..:...  ::|||
Mouse     3 DYDEVIA-FLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLS--SSWRN 64

  Fly   145 LSGSVD---------NCRRW----------------EGIDWSQVSNETTLPSDWKTPAEMDKKLV 184
            .|..::         :|||:                :.:|..|:..|:.|
Mouse    65 HSIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCL--------------- 114

  Fly   185 ACEKWEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFIS 249
              :.|||: .|...:|..::|:||||.:....:....|.:||..|..:||.|||:||||.:||.:
Mouse   115 --DGWEYD-KDIFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFAT 176

  Fly   250 AVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTI---AGMYNLFPL 311
            ..:||.|.......:::|::..|.|::|:..:|......||..|.:....|.|   .|:...|
Mouse   177 MAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFF-- 239

  Fly   312 PISYMIISGLAYLTQDYQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFN 376
            .|.||::...||..:|::.|.|.:.:||:|...||:.:|||||||:.:.|..|..:||:.|||.|
Mouse   240 AIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMN 304

  Fly   377 GRQLPADYQLTPPTQESST---QDVTY--LFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFG 436
            ....||........||.::   |.|..  |||:..:..|::....:|...::.|:.:.||:.:..
Mouse   305 SIVAPAGIFDPLELQELNSLKQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLH 369

  Fly   437 GNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLIC-AGVACCCAAITEGHADLLWLKITF 500
            |:||||..|:||:|:||...|..::..:.::::....|.. .||......:.|   |..::.|..
Mouse   370 GDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPE---DYNFVSIGL 431

  Fly   501 LMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTP---YLSLLNKIEGHLLMT 562
            :|:|||.|::..:::.|:|||||||.:||:.||..::|:.:..|:.|   ||...|::..::||.
Mouse   432 VMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMG 496

  Fly   563 LLTAWSIFGGFVVLFLPET 581
            .||   :..|.:.||.||:
Mouse   497 SLT---VLIGIITLFFPES 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	156/527 (30%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	120/368 (33%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	157/529 (30%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	126/394 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010