DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	138/542 - (25%)
Similarity:	236/542 - (43%)	Gaps:	68/542 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 MGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWC-------QRPAQLQHMPVATWRNLS 146
            :|..|::|:.|.|:|::..:.::.|.....:.||.....|       .|......|.:.|...:.
  Rat    10 VGDRGRFQIWMIVVLNILSMVSSLHDVIENFTAAIPAHHCSVNLLDTSRSEISMAMNLTTEAMMK 74

  Fly   147 GSV--------DNCRR-----WEGIDWS-QVSNETTLPSDWKTPAEMDKKLVAC-EKWEYETNDN 196
            .|:        :.|||     |:.||.: ..||.|.|.::            .| :.|.|: :..
  Rat    75 VSIPMGPNQKPEQCRRFRHPQWQFIDSNISTSNSTELETE------------PCLDGWTYD-HSV 126

  Fly   197 VGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLY 261
            ..:|..::|||||:.:..|..|:...|.|........|.:||:||||.:|...::...|.|....
  Rat   127 FTSTIVTEWDLVCDFQSFKYYAQATSLAGHFVAAPFCGIISDRFGRKPLLMYCSLAYGILGTCCA 191

  Fly   262 ICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWR-TIAGMYNLFPLPISYMIISGLAYLT 325
            ...:|.||..||.|....:.:|..:.|||.:|....:|. |:..:..||. ......:.||||:.
  Rat   192 FVPNFSLYCVLRFLSSASASTVGMNCLILVLEETSVQWHATVIVLSGLFS-STGLAGLGGLAYVL 255

  Fly   326 QDYQRLQLCIGIPG--IFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTP 388
            .|:..:||...:|.  .|:.|.|  ||||.|||::.|:.|:..:.::..|..||::..|....|.
  Rat   256 SDWHLIQLTSALPYFIFFILFCW--VPESARWLMITGKTDQALKELQRIASINGKKDIAQNLTTE 318

  Fly   389 PTQESSTQDVTYLFR---------SSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSA 444
            ..:....:||....:         :..:|:|.:|:..:.|......:|::|::...|.|:::...
  Rat   319 DLRSKVKEDVCSTVKHFSIKDIIINPMIRKIVLCYSSVLFAELFSIFGLLLDVHMLGKNIFVTQI 383

  Fly   445 LAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEG-HADLLWLKITFLMMGKFTI 508
            |.|:::||:.::..:|:..|.::.|....|...|   .|..||.. ..|:..|::...::||...
  Rat   384 LLGVIDIPSKSLTYFILRNVRRRPLIAFLLFATG---GCITITMFLSEDMYVLRLAIFILGKGCF 445

  Fly   509 SAGNTIMPVYTAELYPTPIRNVGVG-------ACNVAAGLALILTPYLSLLNKIEGHLLMTLLTA 566
            :|..:|...|..||.|.|:|:...|       ..:|.:.|.|:...|..||..|...:|..:.|
  Rat   446 AAFISINTAYCNELSPVPLRSTLNGIYISVARLASVLSALTLVTRKYFVLLPMIFCGVLPIVAT- 509

  Fly   567 WSIFGGFVVLFLPETAVRQKTD 588
                  ..:.|||||.....||
  Rat   510 ------INIYFLPETFNHPITD 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	134/532 (25%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	97/376 (26%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	138/541 (26%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	105/401 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020