DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and SLC22A24

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	571	Identity:	142/571 - (24%)
Similarity:	245/571 - (42%)	Gaps:	92/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 DVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPV----ATWR 143
            ||:.|.:|..|::|:   .|::.|.:.|.....:.:.:    :|....|:....:|:    ....
Human     4 DVLLDQVGGMGRFQI---CLIAFFCITNILLFPNIVLE----NFTAFTPSHRCWVPLLDNDTVSD 61

  Fly   144 NLSGSV------------------DNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVAC-EKW 189
            |.:|::                  ..|:|:....|..:....|.|:..:...|      .| :.|
Human    62 NDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTE------PCVDGW 120

  Fly   190 EYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQT 254
            .|:.:..: :|..::||||||.:.||::.:..|:.|...||:|.|:|||:.|||.:..:..:...
Human   121 VYDRSSFL-STIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLA 184

  Fly   255 IFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIIS 319
            |.........:|.:|..||.|.|..::::..:..||::|:...:.|::..|..|....:..|::.
Human   185 ISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLG 249

  Fly   320 GLAYLTQDYQRLQLCIGIPGIFLCFL--WFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPA 382
            |||:..||:..|||.:..| |.:.||  |.:| ||.|||::..::||..:.:...|..||::
Human   250 GLAFAIQDWHILQLTVSTP-IIVLFLSSWKMV-ESARWLIINNQLDEGLKELRRVAHINGKK--- 309

  Fly   383 DYQLTPPTQESSTQD------------------VTYLFRSSYLRR--ISICFFCIWFTMNLVYYG 427
                  .|:|:.|.:                  :..|||:..||.  ..:||  :.|.:.:.:||
Human   310 ------NTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMRVFGLCF--VRFAITVPFYG 366

  Fly   428 IILNMSSFGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHAD 492
            :|||:...|.||.|...|.|.|...|..|::..:..:|::  ....|....|.......|....:
Human   367 LILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRR--ISQILFTFPVGLFILVNTFLPQE 429

  Fly   493 LLWLKITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEG 557
            :..|::....:|..::||.:....|:..||.||.:|:...|...|:......|.|.|..|.....
Human   430 MQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSP 494

  Fly   558 HLLMTLLTAWSIFGGF------VVLFLPETA------VRQKTDNQGGSSAN 596
            ||      .|..:|.|      |:|.||||.      ..|..:|....|.|
Human   495 HL------PWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENDRKDSRN 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	133/541 (25%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	102/384 (27%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	115/434 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.010