DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	155/571 - (27%)
Similarity:	263/571 - (46%)	Gaps:	81/571 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 EDETDVIGDLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVATWR 143
            :|..:.:|: .|.:.|...|:..|:|....|....|   ::.......:||.|...:......|.
  Rat     5 DDVLEQVGE-FGWFQKQAFLLLCLISASLAPIYVGI---VFLGFTPGHYCQNPGVAELSQRCGWS 65

  Fly   144 NL---------------SGSVDNCRRWEGIDWSQ------------VSNETTLPSDWKTPAEMDK 181
            ..               :..:..|.|:| :||:|            |:|.:.||
  Rat    66 QAEELNYTVPGLGPSDEASFLSQCMRYE-VDWNQSTLDCVDPLSSLVANRSQLP----------- 118

  Fly   182 KLVACEK-WEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTM 245
             |..||. |.|:|   .|::..::::|||......::.:....||...|.::.||::|:||||..
  Rat   119 -LGPCEHGWVYDT---PGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLC 179

  Fly   246 LFISAVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYV-DGKWRTIAGMYNLF 309
            |.::.::.::.|:...:...:...|..|.|.|:||.....||..|..|:| .|..||.|.:|.:
  Rat   180 LLVTTLVTSVSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQM- 243

  Fly   310 PLPISYMIISGLAYLTQDYQRLQLCIGIPG-IFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAA 373
            ...:..:.::|:||...|::.|||.:.:|. :||.:.|| |||||||||.:.|.....||:|..|
  Rat   244 AFTVGLVGLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWF-VPESPRWLLSQKRTTRAVRIMEQIA 307

  Fly   374 KFNGRQLPADYQ---LTPPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSF 435
            :.||:..|||.:   |.....|..:.....|||:..||:.::....:||:..::|.|:|:::.:.
  Rat   308 QKNGKVPPADLKMLCLEEDASEKRSPSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGAT 372

  Fly   436 GGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITF 500
            |.|:||:...:.|||.||..:.:..|.::|:.:...|:.:..| |.|...|...| :|.||.:|.
  Rat   373 GANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTG-AACLLMIFIPH-ELHWLNVTL 435

  Fly   501 LMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLT 565
            ..:|:...:....::.:..||||||.|||:|:..|:....|..|.||:          ::..|:.
  Rat   436 ACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPF----------MVFRLME 490

  Fly   566 AWS-----IFG------GFVVLFLPET---AVRQKTDNQGGSSANASAAKQ 602
            .|.     :||      |.:.|.||||   |:.:..:.........|.||:
  Rat   491 VWQALPLILFGVLGLTAGAMTLLLPETKGVALPETIEEAENLGRRKSKAKE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	147/534 (28%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	114/372 (31%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	151/546 (28%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	121/406 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020