DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6006 and SV2C

DIOPT Version :10

Sequence 1:NP_001097812.1 Gene:CG6006 / 41962 FlyBaseID:FBgn0063649 Length:603 Species:Drosophila melanogaster
Sequence 2:NP_055794.3 Gene:SV2C / 22987 HGNCID:30670 Length:727 Species:Homo sapiens


Alignment Length:542 Identity:107/542 - (19%)
Similarity:169/542 - (31%) Gaps:203/542 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 LGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSSFELYLTLRALLGL-----VSVSV 283
            ||:..|....|.|:||.|||..|.|...:...|.........:..:|..|.|.|.     :....
Human   199 LGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVF 263

  Fly   284 TYSGLILA-------IEYVDGKWRTIAGMYNLFPLPISYMII--------SGLAYLTQDYQRLQL 333
            :|...:||       :.::...| .|.|:|   ...:::.||        .|.||....::...:
Human   264 SYFAEVLAREKRGEHLSWLCMFW-MIGGIY---ASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVI 324

  Fly   334 CIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFN--GRQLPADY----QLTPPTQ- 391
            ...:|.:........:|||||:||..|:.||...|::.....|  .|..|...    ::..|.| 
Human   325 VCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQI 389

  Fly   392 ------ESSTQD-----------------VTYLFRSSY-LRRISICFFCIWFTMNLVYYGIIL-- 430
                  ||.|..                 :|::...:| :|..:|....:|||::..|||:.:  
Human   390 DELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWF 454

  Fly   431 ----------------------------------------------------------------- 430
                                                                             
Human   455 PDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKS 519

  Fly   431 ---------------------------------------NMSSFGGN---------------VYL 441
                                                   |.|.|...               :|.
Human   520 CTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYF 584

  Fly   442 NSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITFLMM--- 503
            .:.|..|..:|...|:..::.::|:..:...:::.:|::|.          .||...:..||   
Human   585 VNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCF----------FLWFGTSESMMIGM 639

  Fly   504 ----GKFTISAGNTIMPVYTAELYPTPIRNVGVG----ACNVAAGLA-LILTPYLSLLNKIEGHL 559
                ...||||.|: :.|.|.|||||..|..|.|    .|..||.|. ||....:|:...|...|
Human   640 LCLYNGLTISAWNS-LDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILL 703

  Fly   560 LMTLLTAWSIFGGFVVLFLPET 581
            ..|:|    :.||.|.|.||:|
Human   704 ASTVL----VCGGLVGLCLPDT 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6006NP_001097812.1 MFS_SLC22 189..579 CDD:340875 104/538 (19%)
SV2CNP_055794.3 synapt_SV2 1..727 CDD:130366 107/542 (20%)
Interaction with SYT1. /evidence=ECO:0000250 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..84
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781 519..563 2/43 (5%)
Blue background indicates that the domain is not in the aligned region.

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