DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	549	Identity:	138/549 - (25%)
Similarity:	234/549 - (42%)	Gaps:	58/549 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 MGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPA-----------------QLQH 136
            :|..|::|:|..:.:.:....:..|.....:.||.....|..|.                 .|..
Mouse    10 IGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIPSHRCWVPILDNDTASDNGSRILSQDDLLR 74

  Fly   137 MPVATWRNLSGSVDNCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKLVAC-EKWEYETNDNVGNT 200
            :.:....||  ..|.|||:....|..:....|.|    |..|.|.:  .| :.|.|:.:..:..|
Mouse    75 ISIPLDSNL--RPDKCRRYIQPQWHLLHLNGTFP----TVTEPDTE--PCVDGWVYDQSTFLSTT 131

  Fly   201 WTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQTIFGLWLYICSS 265
            .| ||||||..:.|.:||:..::.|:..|.|:.|:||||||||.:...|.:...|....:....|
Mouse   132 VT-QWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRKLIFTCSLLKMAITETCVAFAPS 195

  Fly   266 FELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQR 330
            |.:|.:||.|.|:.|.::..:..:|.:|:...|::.:..........:...::.|||:..:::..
Mouse   196 FLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALVMALIFIASGVGQTLLGGLAFAFRNWHH 260

  Fly   331 LQLCIGIPGIFLCFL---WFVVPESPRWLLVKGRIDEVRRIIEAAA-----KFNGRQLPADY--- 384
            |||.:.:| :||..:   |  :.||.|||::..:..:..:.::.||     |.:|..|..:.
Mouse   261 LQLALSVP-MFLLLIPTRW--LSESARWLIMANKPQKSLKELKKAACVNRIKNSGDALTLEVVKT 322

  Fly   385 ----QLTPPTQESSTQDVTYLFRSSYLR-RISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSA 444
                :|.....:.|..|   |||:..|| ||.:..| :.|...:...|:::|:.....||:|...
Mouse   323 IMKEELEAAQTKPSPLD---LFRTPNLRKRICLLSF-VRFVSVMSLLGLLINIQYLSNNVFLLQC 383

  Fly   445 LAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADLLWLKITFLMMGKFTIS 509
            |.|:|.|||..:..:.:..:|::......:...|::............:  |::....:|....|
Mouse   384 LYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEMQI--LRVFLSTLGGAISS 446

  Fly   510 AGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGHLLMTLLTAWSIFGGFV 574
            |..|...|:..||.||.||...:|...:|......|:|.|.:|......|...:.......||.|
Mouse   447 ASITSTLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSASLPWIIYGILPFLGGLV 511

  Fly   575 VLFLPETAVR------QKTDNQGGSSANA 597
            .|.||||..:      |..:|:..||..|
Mouse   512 ALLLPETKNQPLPDSIQDIENKRKSSKEA 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	131/524 (25%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	93/372 (25%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	133/531 (25%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010