DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6006 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_033229.3	Gene:	Slc22a12 / 20521	MGIID:	1195269	Length:	553	Species:	Mus musculus

Alignment Length:	543	Identity:	129/543 - (23%)
Similarity:	227/543 - (41%)	Gaps:	80/543 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVAT-----WRNLS 146
            |.:|..|::||..||.|                  .....|......|::...|.     |..|
Mouse     8 DRVGGLGRFQLFQTVAL------------------VTPILWVTTQNMLENFSAAVPHHRCWVPL- 53

  Fly   147 GSVDN-------------------------------CRRWEGIDWSQVSNETTLPSDWKTPAEMD 180
              :||                               |.|:....| |::......::|.     |
Mouse    54 --LDNSTSQASIPGDLGPDVLLAVSIPPGPDQQPHQCLRFRQPQW-QLTESNATATNWS-----D 110

  Fly   181 KKLVACEK-WEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKT 244
            .....||. |.|: :....:|..:.|||||..:.|:.:|:..||.|:..|..:.|:.||:|||:.
Mouse   111 AATEPCEDGWVYD-HSTFRSTIVTTWDLVCNSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRR 174

  Fly   245 MLFISAVLQTIFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLF 309
            :|..|.:|.::.|.......:|.||...|.||......|..:...|.:|:...:...:....|..
Mouse   175 VLTWSYLLVSVSGTAAAFMPTFPLYCLFRFLLASAVAGVMMNTASLLMEWTSAQGSPLVMTLNAL 239

  Fly   310 PLPISYMIISGLAYLTQDYQRLQLCIGIP-GIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAA 373
            ......::...:||..:.::.|||.:..| .:|..:.|: :|||.|||:..|::|:..:.::..|
Mouse   240 GFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWW-LPESARWLITVGKLDQGLQELQRVA 303

  Fly   374 KFNGRQLPADYQLT----------PPTQESSTQDVTYLFRSSYLRRISICFFCIWFTMNLVYYGI 428
            ..|.|:...| .||          .|:::.:...:..|..:..||..:|.....||.....:||:
Mouse   304 AVNRRKAEGD-TLTMEVLRSAMEEEPSRDKAGASLGTLLHTPGLRHRTIISMLCWFAFGFTFYGL 367

  Fly   429 ILNMSSFGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWLFCATLICAGVACCCAAITEGHADL 493
            .|::.:.|.|::|..||.|:|:.|....::.:|:::|::....:.|:..|: |..:.|...|. :
Mouse   368 ALDLQALGSNIFLLQALIGIVDFPVKTGSLLLISRLGRRLCQVSFLVLPGL-CILSNILVPHG-M 430

  Fly   494 LWLKITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSLLNKIEGH 558
            ..|:....::|...:....|.:.::::||:||.||...||.|.|||....:|.|.:.||......
Mouse   431 GVLRSALAVLGLGCLGGAFTCITIFSSELFPTVIRMTAVGLCQVAARGGAMLGPLVRLLGVYGSW 495

  Fly   559 LLMTLLTAWSIFGGFVVLFLPET 581
            :.:.:.....:..|...|.||||
Mouse   496 MPLLVYGVVPVLSGLAALLLPET 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	126/538 (23%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	92/367 (25%)
Slc22a12	NP_033229.3	2A0119	11..526	CDD:273328	128/540 (24%)
Slc22a12	NP_033229.3	MFS	147..516	CDD:119392	93/372 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020