Protein Alignment CG6006 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_001097812.1
• Gene: CG6006 / 41962
• FlyBaseID: FBgn0063649
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 596
• Identity: 152/596 - (25%)
• Similarity: 252/596 - (42%)
• Gaps: 120/596 - (20%)

  Fly    87 DLMGHYGKWQLLMTVLLSLFQVPNTFHISSSIYQAANKDFWCQRPAQLQHMPVAT-----W---- 142
            ||:|..|::|:|.|:.|.:           ||       .|....:.|::...|.     |
Human     8 DLVGGLGRFQVLQTMALMV-----------SI-------MWLCTQSMLENFSAAVPSHRCWAPLL 54

  Fly   143 ------RNLSGSVD------------------NCRRWEGIDWSQVSNETTLPSDWKTPAEMDKKL 183
                  .::.||:.                  .|||:....|..:....|..| |   :|.|.:
Human    55 DNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATS-W---SEADTE- 114

  Fly   184 VAC-EKWEYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLF 247
             .| :.|.|: .....:|..::|:|||:...||.:|:..:|.|:..|....|..||:|||:.:|.
Human   115 -PCVDGWVYD-RSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLT 177

  Fly   248 ISAVLQTIFGLWLYICSSFELYLTLRALL-----------GLVSVSVTYS--------------G 287
            .|.:...:.|.......:|.:|...|.||           |.:..|:|:.              |
Human   178 WSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLG 242

  Fly   288 LILAIEYVDGKWRTIAGMYNLFPLPISYMIISGLAYLTQDYQRLQLCIGIPGIFLCFL--WFVVP 350
            |:..:|:...:.|.:....|.......:.:.:.:||..:|:..|||.:.:| .|||||  |::.
Human   243 LLAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVP-FFLCFLYSWWLA- 305

  Fly   351 ESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADYQLTPPTQESSTQD----------VTYLFRSS 405
            ||.||||..||:|...:.:...|..||:....| .|||....|:.::          :..|.|..
Human   306 ESARWLLTTGRLDWGLQELWRVAAINGKGAVQD-TLTPEVLLSAMREELSMGQPPASLGTLLRMP 369

  Fly   406 YLR-RISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSALAGLVEIPAIAVAMYIITKVGKKWL 469
            .|| |..|...| ||.....::|:.|::.:.|.|::|.....|:|:|||...|:.:::.:|::..
Human   370 GLRFRTCISTLC-WFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPT 433

  Fly   470 FCATLICAGVACCCAAITEGHADLLWLKITFLMMGKFTISAGNTIMPVYTAELYPTPIRNVGVGA 534
            ..|:|:.||:  |..|.|....::..|:....::|...:.|..|.:.:|::||:||.:|...||.
Human   434 LAASLLLAGL--CILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGL 496

  Fly   535 CNVAAGLALILTPYLSLLNKIEGHLLMTLLTAW-SIFGGFVVLFLPET---------------AV 583
            ..:||....||.|.:.||. :.|..|..|:... .:..|...|.||||               ||
Human   497 GQMAARGGAILGPLVRLLG-VHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAV 560

  Fly   584 RQKTDNQGGSS 594
            ::.|....|:|
Human   561 KKATHGTLGNS 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	143/563 (25%)
		MFS	222..579	CDD:119392	107/395 (27%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	145/571 (25%)
		MFS	122..541	CDD:119392	116/426 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020