DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6006 and slc22a2

DIOPT Version :9

Sequence 1:	NP_001097812.1	Gene:	CG6006 / 41962	FlyBaseID:	FBgn0063649	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	XP_002933908.1	Gene:	slc22a2 / 100487774	XenbaseID:	XB-GENE-965056	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	150/533 - (28%)
Similarity:	261/533 - (48%)	Gaps:	62/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DLMGHYGKWQ-------LLMTVLLSLFQ-----------VPNTFHISSSIYQAANKDFWCQRPAQ 133
            :|:.|.|::.       :|:..:..:|.           ||:...:|:.|.:.:|:..|
Frog     6 ELLEHIGEFDAFQKQIFILLCFISVVFSPIYVGIVFLGFVPDYRCVSAGIPEPSNECEW------ 64

  Fly   134 LQHMPVATWRNLSGSVDN-----CRRWEGIDWSQVS---NETTLPSDWKTPAEMDKKLVAC-EKW 189
                 ...:...:||.|:     |.::: :||:..|   ..::|....|.|      :..| :.|
Frog    65 -----TLNYTGPNGSTDSLYMSQCYQYD-VDWNSTSLNCTNSSLNITSKLP------ITNCKDGW 117

  Fly   190 EYETNDNVGNTWTSQWDLVCEKEHLKNVAEMFFLLGVATGGIISGYLSDKFGRKTMLFISAVLQT 254
            :|.|   .|::..::::|||......:..:....:|...||:||||::|:||||..|..|.::..
Frog   118 DYNT---TGSSLVTEFNLVCGDSWKLDFFQSCVNIGFFIGGLISGYIADRFGRKPFLISSILITG 179

  Fly   255 IFGLWLYICSSFELYLTLRALLGLVSVSVTYSGLILAIEYVDGKWRTIAGMYNLFPLPISYMIIS 319
            |||:.:....::.|.:|.|.:.|.||.....||.||..|:|..:.|...|:.......:..:::|
Frog   180 IFGILMAFAPNYPLVVTFRFIQGFVSKGCWLSGYILVAEFVGLEHRRTVGIVYQAAFTVGLLLLS 244

  Fly   320 GLAYLTQDYQRLQLCIGIPGIFLCFLWFVVPESPRWLLVKGRIDEVRRIIEAAAKFNGRQLPADY 384
            |:||:...::.||:.:.||..|....::.||||||||:.:.|..|.:.||...||.||:.:| |:
Frog   245 GVAYVLPHWRWLQMTVTIPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVP-DF 308

  Fly   385 --QLTPPTQESSTQDVTY--LFRSSYLRRISICFFCIWFTMNLVYYGIILNMSSFGGNVYLNSAL 445
              .||...:....|..::  |.|:..:|:.::....||||..:||.|.|::|.|...|:|.:..:
Frog   309 LESLTADEEAGEKQVPSFLDLVRTPQIRKHTLILMYIWFTCAVVYQGSIMHMGSTAENIYFDFFI 373

  Fly   446 AGLVEIPAIAVAMYIITKVGKK--WLFCATLICAGVACCCAA-ITEGHADLLWLKITFLMMGKFT 507
            :.|||.|:..:.:..:.:||::  ||.|.  |..|:.|...| |..|::   ||.||...:.:..
Frog   374 SALVEFPSAILIIVTVDRVGRRYPWLVCC--IITGITCLITAFIPHGYS---WLIITLSCVSRMG 433

  Fly   508 ISAGNTIMPVYTAELYPTPIRNVGVGACNVAAGLALILTPYLSL-LNKIEGHLLMTLLTAWSIFG 571
            |:....::.:..||||||.|||:|:..|:....|..::||::.. |..|...|.:.:....:...
Frog   434 ITVSYEMVCLVNAELYPTFIRNLGIMVCSSMCDLGGVITPFIVYRLAAIWQELPLIVFAVLATVS 498

  Fly   572 GFVVLFLPETAVR 584
            |.:|.|||||..|
Frog   499 GILVYFLPETKGR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6006	NP_001097812.1	2A0119	90..581	CDD:273328	146/525 (28%)
CG6006	NP_001097812.1	MFS	222..579	CDD:119392	116/364 (32%)
slc22a2	XP_002933908.1	2A0119	12..516	CDD:273328	148/527 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010