DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fer2 and NEUROG2

DIOPT Version :9

Sequence 1:	NP_001287359.1	Gene:	Fer2 / 41961	FlyBaseID:	FBgn0038402	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_076924.1	Gene:	NEUROG2 / 63973	HGNCID:	13805	Length:	272	Species:	Homo sapiens

Alignment Length:	212	Identity:	55/212 - (25%)
Similarity:	79/212 - (37%)	Gaps:	71/212 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SSSPPISHL-PFHNFDDDLINDLPSCIYAGQHQGGGATGGGGGSGGGGGSSGLRLSSNNLRHIQQ 73
            |:||.::.| |..:..|:...:.|......:.|.|...|.|...|...|:.|.|
Human    22 SASPALAALTPLSSSADEEEEEEPGASGGARRQRGAEAGQGARGGVAAGAEGCR----------- 75

  Fly    74 HYMQHSGENLLDSSTNPMG-VHNSGGGAPLMC-NSPSASSSGGGCGNAGSATPGGAGGPNPGYGS 136
                         ....:| ||:        | ..||.:.:                      .|
Human    76 -------------PARLLGLVHD--------CKRRPSRARA----------------------VS 97

  Fly   137 VGAATASSY----KMQRQAANVRERKRIQRSAPTGYTKCSINSAFDELRVHVPTFPYEKRLSKID 197
            .||.||.:.    |.:|..||.|||.|:.          ::|:|.|.||..:||||.:.:|:||:
Human    98 RGAKTAETVQRIKKTRRLKANNRERNRMH----------NLNAALDALREVLPTFPEDAKLTKIE 152

  Fly   198 TLRLAIAYISLLREVLQ 214
            |||.|..||..|.|.|:
Human   153 TLRFAHNYIWALTETLR 169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fer2	NP_001287359.1	HLH	148..210	CDD:278439	25/61 (41%)
NEUROG2	NP_076924.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..69		9/38 (24%)
		bHLH_TS_NGN2_ATOH4	104..172	CDD:381560	29/76 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..264
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910