DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fer2 and PTF1A

DIOPT Version :9

Sequence 1:	NP_001287359.1	Gene:	Fer2 / 41961	FlyBaseID:	FBgn0038402	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_835455.1	Gene:	PTF1A / 256297	HGNCID:	23734	Length:	328	Species:	Homo sapiens

Alignment Length:	186	Identity:	70/186 - (37%)
Similarity:	85/186 - (45%)	Gaps:	53/186 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LRHIQQHYMQHSGENLLDSSTNP-----MGVHNSGGGAPLMCNSPSASSSGGGCGNAGSATPGG- 126
            |.|....|....|..||.....|     :...:|||     ...|.....||.|...| |.|||
Human    53 LSHQLHEYCYRDGACLLLQPAPPAAPLALAPPSSGG-----LGEPDDGGGGGYCCETG-APPGGF 111

  Fly   127 ---AGGP--------------NPG---YGSVGAATASSYKMQ-----------RQAANVRERKRI 160
               .|.|              :||   .|..|||.|::.:.:           |||||||||:|:
Human   112 PYSPGSPPSCLAYPCAGAAVLSPGARLRGLSGAAAAAARRRRRVRSEAELQQLRQAANVRERRRM 176

  Fly   161 QRSAPTGYTKCSINSAFDELRVHVPTFPYEKRLSKIDTLRLAIAYISLLREVLQTD 216
            |          |||.||:.||.|:||.||||||||:|||||||.||:.|.|::|.|
Human   177 Q----------SINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQAD 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fer2	NP_001287359.1	HLH	148..210	CDD:278439	38/72 (53%)
PTF1A	NP_835455.1	HLH	165..220	CDD:238036	40/64 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..278
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2562
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840