DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and USP6

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001291213.1	Gene:	USP6 / 9098	HGNCID:	12629	Length:	1406	Species:	Homo sapiens

Alignment Length:	307	Identity:	76/307 - (24%)
Similarity:	132/307 - (42%)	Gaps:	34/307 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RRRM----KWEAILQQNTDLTQVDAKLKRYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLL 101
            ||.|    ||..:|.: .:..:..:||...:.||||...|..||..:......:.::|..::.:.
Human    68 RREMTRTSKWMEMLGE-WETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMK 131

  Fly   102 RTEPFDKEISDSISIDLPRTFPDNIHF----DMKKQRLYNILIAYAHHNRDVGYCQGLNYIAGLL 162
            .......|....|.:|:..|..:::.|    ..|::.|:.||:||:.:|.:||||:.|::|..|.
Human   132 ERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALF 196

  Fly   163 LIVTDDEEKSFWLLKHIV---ENIVPQYHSHNMANL--LRDLAVFRELVIRRIPAVNRHVDNLGL 222
            |:.. .||.:||.|..::   .:.:|.:||.|...:  |:|..  ..:|.:..|....|.|..||
Human   197 LLYL-PEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQ--EHVVPKSQPKTMWHQDKEGL 258

  Fly   223 PYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGYKIVFR-AALTMFVTHKNAI--LGCDDIAAL 284
            .....:....:....:.:.:...||:||....||.:::.. .::.:.|..|..:  ..|...|.|
Human   259 CGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARL 323

  Fly   285 ANLFRDT--MIQDNIVTDCHGFVEAMFSLRLKRSELESLRKVAVLNP 329
            .|.|.||  |..|.::.            .|:.|..:..||...|.|
Human   324 RNQFFDTWAMNDDTVLK------------HLRASTKKLTRKQGDLPP 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	53/220 (24%)
USP6	NP_001291213.1	TBC	97..312	CDD:214540	53/217 (24%)
		DUF4607	<332..407	CDD:292024	8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..380		4/11 (36%)
		UBP12	<528..1114	CDD:227847
		Peptidase_C19	533..>723	CDD:271592
		Peptidase_C19	<1023..1367	CDD:271592
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1384..1406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810