DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and MSB3

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_014106.1	Gene:	MSB3 / 855423	SGDID:	S000005237	Length:	633	Species:	Saccharomyces cerevisiae

Alignment Length:	417	Identity:	112/417 - (26%)
Similarity:	184/417 - (44%)	Gaps:	101/417 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ATASSKFSD------VDEYGFKR-GDHFDYNNYSKFMDGYLKTLTRRRMKWEAILQQN----TD- 55
            |:|:|..|:      .|.||||: .::.....|.|:...|.:...||:.||:.:|:::    ||
Yeast   140 ASATSANSNGINNTHFDRYGFKKQNNYISEAEYDKWWVEYSQYCVRRKHKWQLLLEKSGLPVTDD 204

  Fly    56 ----LTQVDAKLKRYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLLR-------TEPFDKE 109
                ......:||||:|||||..:|.:.|...:.......::..::..|||       ..|.:|:
Yeast   205 SPSRFPSKSERLKRYVRKGIPAEWRGNAWWHFARGQEKLNKNKGVYSQLLRKMKQIKKQNPNEKQ 269

  Fly   110 IS--DSISIDLPRTFPDNIHFDMKKQRLYN------------ILIAYAHHNRDVGYCQGLNYIAG 160
            :.  |.|..||.|||||||||   :..|:|            :|:|::.:|..:||||.:|::||
Yeast   270 VQDLDIIERDLNRTFPDNIHF---QSSLHNKEGPPIIKSLRRVLVAFSLYNPKIGYCQSMNFLAG 331

  Fly   161 LLLIVTDDEEKSFWLLKHIVENIVPQYHSHNMANLLRDLAVFRELVIRRI--------PAVNRHV 217
            |||:.. |||::||:|..|....:|..|:.|:..:..|..|....|...|        |:::.|.
Yeast   332 LLLLFL-DEERAFWMLVIITSRYLPGVHNINLEGVNIDQGVLMLCVKEYIPEVWSYIKPSIDHHQ 395

  Fly   218 DNLGL----------------------PYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGYKIV 260
            .|...                      |..:..:.||:..|..|:|:||.||||||:|.|....:
Yeast   396 KNNKTFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFL 460

  Fly   261 FRAALTMF------------------------VTHKNAILGCDD----IAALANLFRDTMIQDNI 297
            |:.:|.:.                        :..:...:|.:|    |..:...|..|::..|.
Yeast   461 FKVSLAVLKLSEHDLSKIKPRNNSLNYSWGSNLNQRGGSMGQEDSDMEIFQVIQTFPKTLLNPNE 525

  Fly   298 VTDCHGFVEAMFSL-RLKRSELESLRK 323
            :.:...| :..|:| ||.:.|::..||
Yeast   526 IFEKIIF-KRRFNLNRLDQDEIDRCRK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	75/283 (27%)
MSB3	NP_014106.1	COG5210	15..540	CDD:227535	107/404 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H84592
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1275
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003486
OrthoInspector	1	1.000	-	-		otm46789
orthoMCL	1	0.900	-	-		OOG6_100958
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	1	1.000	-	-		X2377
TreeFam	1	0.960	-	-
	11	10.850