DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and GRTP1

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_001273661.1	Gene:	GRTP1 / 79774	HGNCID:	20310	Length:	344	Species:	Homo sapiens

Alignment Length:	317	Identity:	138/317 - (43%)
Similarity:	198/317 - (62%)	Gaps:	9/317 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDATASSKFSDVDEYGFKRGDHFDYNNYSKFMDGYLKTLTRRRMKWEAILQQNTDLTQVDAKLKR 65
            |.....|:...:|.|||:|.:.||...|.||...||.|||||.:||..:||...  ......:||
Human     1 MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGG--VPRSRTVKR 63

  Fly    66 YIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLLRTEPFDKEISDSISIDLPRTFPDNIHF-- 128
            |:|||:|..:|..|||.:|||.|...::|..:..||:.|. :..:.|:|..||.||||||:.|
Human    64 YVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGER-NPRLEDAIRTDLNRTFPDNVKFRK 127

  Fly   129 --DMKKQR-LYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIVENIVPQYHSH 190
              |...|| |||:|:||.|||:.||||||:|:|||.|:::|::||:|||||..:|..|:|.|:|.
Human   128 TTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYYSP 192

  Fly   191 NMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVETVLRIWDCVFAE 255
            .|..|..|..|..|||..::|||...::.||:.:.::.|:||||:|.::||||||||||||:|.|
Human   193 AMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNE 257

  Fly   256 GYKIVFRAALTMFVTHKNAILGCDDIAALANLFRDTMIQDNIVTDCHGFVEAMFSLR 312
            |.||:||.|||:...|:..||....:..:.:.|:. :.:.:.|.:||.|::...:.|
Human   258 GSKIIFRVALTLIKQHQELILEATSVPDICDKFKQ-ITKGSFVMECHTFMQVCGAAR 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	104/213 (49%)
GRTP1	NP_001273661.1	TBC	65..278	CDD:214540	104/213 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	205	1.000	Domainoid score	I2941
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84592
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3010
Isobase	1	0.950	-	0	Normalized mean entropy	S2150
OMA	1	1.010	-	-		QHG53652
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	1	1.000	-	-		FOG0003486
OrthoInspector	1	1.000	-	-		oto89929
orthoMCL	1	0.900	-	-		OOG6_100958
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	1	1.000	-	-		X2377
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820