DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and Tbc1d2b

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_919315.2	Gene:	Tbc1d2b / 67016	MGIID:	1914266	Length:	965	Species:	Mus musculus

Alignment Length:	360	Identity:	100/360 - (27%)
Similarity:	166/360 - (46%)	Gaps:	57/360 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDVDEYGFKR--GDHFDYNNYSKFMDGYLKTL-------TRRRMKWEAIL--QQNTDLTQVDAKL 63
            |:.|.|||:.  .|..:....:|.....||||       ....:|||...  ..|.::. ...:|
Mouse   594 SEFDIYGFRTVPDDDEEEKLVAKVRALDLKTLYLTDNQEVSTGVKWENYFASTMNREMA-CSPEL 657

  Fly    64 KRYIRKGIPGPYRPDVW--------MKISGAAAAQRRSPDLFRNLLRTEPFDKE--ISDSISIDL 118
            |..||.|||..:|..||        .|...:     ..||.|:.||: :..:|:  .|..|.:||
Mouse   658 KNLIRAGIPHEHRSKVWKWCVDRHTRKFKDS-----MEPDYFQTLLQ-KALEKQNPASKQIELDL 716

  Fly   119 PRTFPDNIHFDMKK----QRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHI 179
            .||.|:|.|:....    |:|.::|:|::..|.|:|||||||.:..:.|:..|.|: :||.|..|
Mouse   717 LRTLPNNKHYSSPTSEGIQKLRSVLLAFSWRNPDIGYCQGLNRLVAVALLYLDQED-AFWCLVTI 780

  Fly   180 VENIVPQ-YHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVE 243
            ||..:|: |::..:.....|..|||:|:..::|.::.|.:...:.|.:|...||:.:|.:.:..:
Mouse   781 VEVFMPRDYYTKTLLGSQVDQRVFRDLLSEKLPRLHTHFEQYKVDYTLITFNWFLVVFVDSVVSD 845

  Fly   244 TVLRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDDIAALANLFRDTMIQDNIVTDCHGFVEAM 308
            .:.:|||....||.|::||.||.:|...:..||...|   ..::|:........:.|....:...
Mouse   846 ILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD---SMSIFKYLRYFTRTILDARKLISIS 907

  Fly   309 F--------------------SLRLKRSELESLRK 323
            |                    .:||:.:|||::|:
Mouse   908 FGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIRE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	71/223 (32%)
Tbc1d2b	NP_919315.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		PH_TBC1D2A	36..144	CDD:269966
		PH	38..136	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..340
		HIP1_clath_bdg	<341..>378	CDD:293123
		RabGAP-TBC	710..878	CDD:278964	55/168 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100958
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720