DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and tbc1d2

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	XP_689604.6	Gene:	tbc1d2 / 561110	ZFINID:	ZDB-GENE-140106-100	Length:	926	Species:	Danio rerio

Alignment Length:	374	Identity:	107/374 - (28%)
Similarity:	170/374 - (45%)	Gaps:	66/374 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DATASSKFSDVDEYGFKRGDHFDYNNYSKFMDGYLKTLTR---RRMKWEAILQQNT--------- 54
            :|...:..||.|||||:..  .||    |..|  ||.|.:   ...:.:.:|.|..
Zfish   542 NAIKLNPISDYDEYGFRIA--VDY----KVED--LKLLAKIQALEFRSQNLLNQEECDGPLLARC 598

  Fly    55 ----------DLTQVDAKLKRYIRKGIPGPYRPDVW--MKISGAAAAQRRSPDLFRNLL---RTE 104
                      :||. .|::|..:|.|:|..||..||  |..:...:.:.|.||.:..|.   |:.
Zfish   599 AQLLFGRPEGELTS-SAEMKGLLRTGLPHEYRVRVWRFMIQTRTKSLRERHPDRYHELCEKSRSS 662

  Fly   105 PFDKEISDSISIDLPRTFPDNIHFDMKK----QRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIV 165
            |  ..:...|.:||.||...|.||....    |:|..:|.|::.||..:||.||||.:|.:.|:|
Zfish   663 P--HLVPRQIQLDLDRTLTSNKHFSPPTSPLIQKLERVLQAFSWHNPTIGYVQGLNRLAAIALLV 725

  Fly   166 TDDEEKSFWLLKHIVENIV-PQYHSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIAS 229
            ..:|..:||.|..|||:|: |.|.:.::.....|..|.::|::.::|.:..|::.|.:...:|..
Zfish   726 LQEEADAFWCLVVIVEHIMPPNYFTKDLVGCQADQRVLKDLMLEKLPRLTAHLEALKVDISLITV 790

  Fly   230 KWFICIFAEVLPVETVLRIWDCVFAEGYKIVFRAALTMFVTHKNAILGCDDIAALANLFRDTMIQ 294
            :||:.:|.|.||...:.::||.:..||.|::||.||.:|...:.|||...|...:....|   |.
Zfish   791 EWFLVLFVESLPTRILFKVWDALLYEGSKVIFRYALALFKYREEAILKIQDSVEMYQYLR---IF 852

  Fly   295 DNIVTDCHGFVEAMFS----LRLKR----------------SELESLRK 323
            .|.:.|........|:    ||::.                .|||:|:|
Zfish   853 PNTIADGRKLTSIAFNDMNPLRMRLIQNRRAAHLERLHAEIKELENLQK 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	71/218 (33%)
tbc1d2	XP_689604.6	PH	56..146	CDD:278594
		PH_TBC1D2A	57..153	CDD:269966
		TBC	621..837	CDD:214540	71/217 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1162786at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100958
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.720