DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and TBC1D8B

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_060222.2	Gene:	TBC1D8B / 54885	HGNCID:	24715	Length:	1120	Species:	Homo sapiens

Alignment Length:	289	Identity:	79/289 - (27%)
Similarity:	143/289 - (49%)	Gaps:	35/289 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LKTLTRRRMKWEAILQQNTDLTQVDA----------KLKRYIRKGIPGPYRPDVWMKISGAAAAQ 90
            |:||..:.:| |.:.:|:..:...:.          |.:..:.:|||...|.::||..|||....
Human   444 LETLNSKMLK-EKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDM 507

  Fly    91 RRSPDLFRNLLRTEPFDKEI------SDSISIDLPRTFPDNIHF--DMKKQRLYNILIAYAHHNR 147
            ..:||.:     ||..::.:      ::.|..||.|:.|::..|  |.....|..:|.|||:.|.
Human   508 ATNPDYY-----TEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNP 567

  Fly   148 DVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIVENIVPQYHSHNMANLLRDLAVFRELVIRRIPA 212
            .:||||.:|.:..:||:...:|| :||||..:.|.::|.|.:..:...|.|.|||.||:...:|.
Human   568 KIGYCQAMNILTSVLLLYAKEEE-AFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQ 631

  Fly   213 VNRHVDNLGLPYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGYKIVFRAALTMFVTHKNAILG 277
            :..|:.::.. :..::..||:.:|..|||:|:.:.:.||.|.:|.|.:.:..|.:...:.:.:|.
Human   632 LTEHMTDMTF-FSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLT 695

  Fly   278 CDD----IAALANLF-----RDTMIQDNI 297
            |.|    :.||...|     :|:.:..|:
Human   696 CKDDAEAVTALNRFFDNVTNKDSPLPSNV 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	64/216 (30%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159
		TBC	486..694	CDD:214540	64/214 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840