DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5916 and Tbc1d8

DIOPT Version :9

Sequence 1:	NP_001287357.1	Gene:	CG5916 / 41960	FlyBaseID:	FBgn0038401	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	XP_017177250.1	Gene:	Tbc1d8 / 54610	MGIID:	1927225	Length:	1160	Species:	Mus musculus

Alignment Length:	235	Identity:	72/235 - (30%)
Similarity:	121/235 - (51%)	Gaps:	12/235 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 KLKRYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLLRTEPFDK--EISDSISIDLPRTFPD 124
            |:::.:..|||...|..:|:..|.|.......|..:.||:. :...:  .:::.|..||.|:.|:
Mouse   511 KIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVE-QSLGRCCLVTEEIERDLHRSLPE 574

  Fly   125 NIHFDMKK--QRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDEEKSFWLLKHIVENIVPQY 187
            :..|..:.  ..|..:|.||||.|..:||||.:|.:..:||:...:|| :||||..:.|.::|.|
Mouse   575 HPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYAKEEE-AFWLLVAVCERMLPDY 638

  Fly   188 HSHNMANLLRDLAVFRELVIRRIPAVNRHVDNLGLPYPVIASKWFICIFAEVLPVETVLRIWDCV 252
            .:|.:.....|.:||.||:..::|.:..|:.:|. ....|:..||:.:|..::|:|:.:.:.||.
Mouse   639 FNHRVIGAQVDQSVFEELIKEQLPELAEHMSDLS-ALASISLSWFLTLFLSIMPLESAVHVVDCF 702

  Fly   253 FAEGYKIVFRAALTMFVTHKNAILGC---DDIAALANLFR 289
            |.:|.|.:|:..|.  |...||...|   ||..||..|.|
Mouse   703 FYDGIKAIFQLGLA--VLEANAEELCSSKDDGQALMVLSR 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5916	NP_001287357.1	TBC	67..276	CDD:214540	64/212 (30%)
Tbc1d8	XP_017177250.1	PH-GRAM1_TBC1D8	171..269	CDD:270156
		PH-GRAM2_TBC1D8	311..406	CDD:270160
		TBC	519..725	CDD:214540	64/210 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840